2,3-Diaminopyridine
Synonym(s):2,3-Diaminopyridine
- CAS NO.:452-58-4
- Empirical Formula: C5H7N3
- Molecular Weight: 109.13
- MDL number: MFCD00006319
- EINECS: 207-200-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 11:59:05
What is 2,3-Diaminopyridine?
Chemical properties
Brown powder
The Uses of 2,3-Diaminopyridine
2,3-Diaminopyridine was used in the synthesis of 2,3-diaminopyridinium-4-hydroxybenzoate1. It was used as internal standard in analysis of poly(amidoamine)dendrimers having different terminal functionalities by capillary electrophoresis. It was used as reagent in synthesis of imidazopyridines and organometallic complexes.
Synthesis
2,3-Diaminopyridine can be prepared by 2,3-Diamino-5-bromopyridine under basic conditions. The specific synthesis is described below:
In an apparatus for catalytic hydrogenation 56.4 g. (0.3 mole) of 2,3-diamino-5-bromopyridine suspended in 300 ml. of 4% sodium hydroxide solution is shaken with hydrogen in the presence of 1.0 g. of 5% palladized strontium carbonate (Note 14). When absorption of hydrogen is completed, the catalyst is removed by filtration, and, after saturation with potassium carbonate (about 330 g. is required), the resulting slushy mixture is extracted continuously with ether until all the precipitate completely disappears (usually about 18 hours, but this depends on the efficiency of the extraction apparatus). The ether is removed by distillation, and the residue of crude 2,3-diaminopyridine is recrystallized from benzene (about 600 ml. is required) using 3 g. of activated charcoal and filtering rapidly through a preheated Büchner funnel. The yield of 2,3-diaminopyridine, obtained as colorless needles, m.p. 115–116°, pKa 6.84, is 25.5–28.0 g. (78–86%).
General Description
2,3-Diaminopyridine forms the bis-condensed Schiff base with salicylaldehyde. It forms charge transfer complex with tetrachloro-p-benzoquinone and tetracyanoethylene.
Purification Methods
It crystallises from *benzene and sublimes in vacuo. [Beilstein 22/11 V 241.]
Properties of 2,3-Diaminopyridine
Melting point: | 110-115 °C (lit.) |
Boiling point: | 195°C 55mm |
Density | 1.1118 (rough estimate) |
refractive index | 1.5340 (estimate) |
Flash point: | 205 °C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | H2O: soluble50mg/mL, opaque (brown to very dark brown) |
pka | 6.78±0.36(Predicted) |
form | Solid |
color | Very Dark Brown |
Water Solubility | 100 g/L (20 ºC) |
Sensitive | Air Sensitive |
BRN | 109869 |
CAS DataBase Reference | 452-58-4(CAS DataBase Reference) |
NIST Chemistry Reference | 2,3-Pyridinediamine(452-58-4) |
Safety information for 2,3-Diaminopyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,3-Diaminopyridine
InChIKey | ZZYXNRREDYWPLN-UHFFFAOYSA-N |
2,3-Diaminopyridine manufacturer
SGT life sciences
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
Manik Laboratories
GRK RESEARCH LABORATORIES PVT LTD
Sintilla Medcoms Pvt Ltd
Nasense Labs Private Limited
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1,1’-CARBONYLDIIMIDAZOLE DIETHYL AMINOMALONATE HYDROCHLORIDE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
452-58-4 2,3-Diaminopyridine 98%View Details
452-58-4 -
2,3-Diaminopyridine 98%View Details
-
2,3-Diaminopyridine 452-58-4 98%View Details
452-58-4 -
2,3-Diaminopyridine 452-58-4 95-99%View Details
452-58-4 -
452-58-4 2,3-diaminopyridine 99%View Details
452-58-4 -
452-58-4 98%+View Details
452-58-4 -
2,3-Diamino Pyridine CAS 452-58-4View Details
452-58-4 -
2,3-Diaminopyridine, 97% CAS 452-58-4View Details
452-58-4