HYDRAZINE

Description

Hydrazine sulphate, hydrobromide and hydrochloride have been reported to be occupational sensitizers, mainly in soldering flux.

Description

Hydrazine is an extremely toxic and unstable liquid with an ammonia-like odor. It has a wide explosive range (1.8–100%) and a low flash point of 52 °C. Its chief commercial use is as a blowing agent for plastics and metals; it also has many uses in synthesis and analytical procedures. Hydrazine has also been used as a rocket fuel, in part because it is hypergolic with?N2O4, last week’s molecule. Recently, M. Stradiotto and R. J. Lundgren reported the use of a?palladium catalyst?to couple hydrazine with aryl groups.

Description

Hydrazine is a highly toxic liquid with numerous applications in organic chemistry. It has a pungent ammonia-like odor and is highly flammable. It can be purchased in anhydrous form or as the hydrate. Hydrazine is classified as a strong reducing agent and will react readily and exothermically with most oxidizing agents and mineral acids.

The Uses of HYDRAZINE

A mixture of the SM (19.3 g, 75 mmoles) and hydrazine hydrate (18.8 g, 376 mmoles) was heated to 80 C. To the resulting suspension was added KOH (3.37 g, 51 mmoles) and the mixture was stirred at 80 C. Three additional portions of KOH (each 3.37 g, 51 mmoles) were added at 20 min intervals and the temp was raised to 110 C. After stirring overnight, the reaction mixture was acidified with cold portions of conc aq HCl. The product was extracted using MTBE (2 x 100 mL). The combined organics were washed with H2O (2 x 50 mL), brine (25 mL), and concentrated in vacuo until solids began to crystallize out of solution. The solids were filtered to provide the product. [US20080293730, page 8]

The Uses of HYDRAZINE

Hydrazine is used as a high-energy rocket fuel, as a reducing agent, and for preparing organic hydrazine derivatives. The propellant grade of commercial hydrazine is more than 97.7% active. It is also used as an oxygen scavenger in boiler water. Hydrazine has also been used as an experimental drug for treating tuberculosis and sickle cell anemia.