4-Dimethylaminopyridine
Synonym(s):DMAP;4-Dimethylaminopyridine;4-(Dimethylamino)pyridine;Valaciclovir Related Compound G (USP);DMAP solution
- CAS NO.：1122-58-3
- Empirical Formula: C7H10N2
- Molecular Weight: 122.17
- MDL number: MFCD00006418
- EINECS: 214-353-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-01 18:08:31
What is 4-Dimethylaminopyridine?
Description
4-(Dimethylamino)pyridine (DMAP) is a toxic, corrosive solid that is widely used as a nucleophilic catalyst in esterification, hydrosilylation, Bayliss–Hillman reactions, and many more. In 2001, G. C. Fu and co-workers showed that chiral derivatives of DMAP can be used for stereoselective catalysis. More recently,?D. Seidel and co-workers used DMAP and other inexpensive reagents in acylation reactions?to give products that can be enantiomerically resolved.
Description
4-Dimethylaminopyridine (DMAP) is a nucleophilic catalyst used for numerous different reactions. DMAP is a very effective acyl transfer agent. The use of 4-aminopyridines (such a DMAP) has been shown to speed up the esterification of hindered alcohols via acid anhydrides by up to 10,000 fold.
The Uses of 4-Dimethylaminopyridine
4-Dimethylaminopyridine (Valaciclovir EP Impurity G; Valacyclovir USP Related Compound G) is a highly efficient catalyst for acylation reactions.
What are the applications of Application
4-Dimethylaminopyridine is a highly efficient catalyst for acylation reactions
Properties of 4-Dimethylaminopyridine
| Melting point: | 112 °C |
| Boiling point: | 162 °C |
| Density | 0.906 g/mL at 25 °C |
| Flash point: | 110 °C |
| storage temp. | Store below +30°C. |
| solubility | methanol: 50 mg/mL, clear |
| form | prilled |
| appearance | White solid |
| color | off-white to yellow |
| Odor | characteristic odor |
| Water Solubility | 76 g/L (25 ºC) |
Safety information for 4-Dimethylaminopyridine
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H310:Acute toxicity,dermal H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H370:Specific target organ toxicity, single exposure H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-Dimethylaminopyridine
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