2,2,2-Trifluoroethyl trifluoromethanesulfonate
Synonym(s):Trifluoromethanesulfonic acid 2,2,2-trifluoroethyl ester
- CAS NO.:6226-25-1
- Empirical Formula: C3H2F6O3S
- Molecular Weight: 232.1
- MDL number: MFCD00671579
- EINECS: 458-390-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-13 09:24:55
What is 2,2,2-Trifluoroethyl trifluoromethanesulfonate?
The Uses of 2,2,2-Trifluoroethyl trifluoromethanesulfonate
2,2,2-Trifluoroethyl trifluoromethanesulfonate is a powerful trifluoroethylating agent which is useful for synthesis of fluorinated amino acids. It is used as a reagent in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines.
The Uses of 2,2,2-Trifluoroethyl trifluoromethanesulfonate
A fluorine-containing alkyl alkanesulfonate with cyctotoxity towards cultured leukemia L1210 cells.
The Uses of 2,2,2-Trifluoroethyl trifluoromethanesulfonate
Reagent used in thenantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines
What are the applications of Application
2,2,2-Trifluoroethyl triflate is A powerful trifluoroethylating agent which is useful for synthesis of fluorinated amino acids.
Synthesis
In a 100-ml flask equipped with a stirrer, a thermometer, a nitrogen introducing pipe, and a condenser, 50 ml (0.297 mol) of trifluoromethane sulfonic anhydride and 25 ml (0.342 moles) of 2,2,2-trifluoroethanol were placed at room temperature and stirred for 30 minutes in a nitrogen atmosphere, followed by reflux for 3 hours. After distillation, 50.3 g of 2,2,2-trifluoroethyl trifluoromethanesulfonate was obtained in a yield of 73%.
Properties of 2,2,2-Trifluoroethyl trifluoromethanesulfonate
Boiling point: | 89-91°C |
Density | 1,61 g/cm3 |
refractive index | 1.3037 |
RTECS | PB2775000 |
Flash point: | >110°(230°F) |
storage temp. | 2-8°C |
solubility | Chloroform, Methanol (Slightly) |
form | Liquid |
color | Colorless to yellow |
Water Solubility | Slightly soluble in water. |
Sensitive | Moisture Sensitive |
CAS DataBase Reference | 6226-25-1(CAS DataBase Reference) |
EPA Substance Registry System | Methanesulfonic acid, trifluoro-, 2,2,2-trifluoroethyl ester (6226-25-1) |
Safety information for 2,2,2-Trifluoroethyl trifluoromethanesulfonate
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H314:Skin corrosion/irritation H330:Acute toxicity,inhalation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,2,2-Trifluoroethyl trifluoromethanesulfonate
InChIKey | RTMMSCJWQYWMNK-UHFFFAOYSA-N |
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