Aminoacetaldehyde dimethyl acetal
Synonym(s):2,2-Dimethoxyethylamine
- CAS NO.:22483-09-6
- Empirical Formula: C4H11NO2
- Molecular Weight: 105.14
- MDL number: MFCD00008135
- EINECS: 245-026-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-05 17:10:12
![Aminoacetaldehyde dimethyl acetal Structural](https://img.chemicalbook.in/CAS/GIF/22483-09-6.gif)
What is Aminoacetaldehyde dimethyl acetal?
Description
Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.
Chemical properties
clear colorless to pale yellow liquid
The Uses of Aminoacetaldehyde dimethyl acetal
Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.
General Description
Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.
Purification Methods
Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]
Properties of Aminoacetaldehyde dimethyl acetal
Melting point: | -78°C |
Boiling point: | 135-139 °C/95 mmHg (lit.) |
Density | 0.965 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 128 °F |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | soluble in Chloroform, Methanol |
pka | 6.95±0.10(Predicted) |
form | Liquid |
color | Clear colorless to pale yellow |
Water Solubility | miscible |
BRN | 741868 |
CAS DataBase Reference | 22483-09-6(CAS DataBase Reference) |
NIST Chemistry Reference | Aminoacetaldehyde dimethyl acetal(22483-09-6) |
EPA Substance Registry System | Ethanamine, 2,2-dimethoxy- (22483-09-6) |
Safety information for Aminoacetaldehyde dimethyl acetal
Signal word | Danger |
Pictogram(s) |
![]() Flame Flammables GHS02 ![]() Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Aminoacetaldehyde dimethyl acetal
InChIKey | QKWWDTYDYOFRJL-UHFFFAOYSA-N |
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