2-Thiophenesulfonyl chloride
- CAS NO.：16629-19-9
- Empirical Formula: C4H3ClO2S2
- Molecular Weight: 182.65
- MDL number: MFCD00005426
- EINECS: 240-677-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is 2-Thiophenesulfonyl chloride?
Chemical properties
2-Thiophenesulfonyl chloride is colorless to brown low melting solid or liquid
The Uses of 2-Thiophenesulfonyl chloride
2-Thiophenesulfonyl chloride is a compound used in the preparation of various pharmaceuticals. Thiophene-2-sulfonyl Chloride was used as an intermediate in the synthesis of β-Cell apoptosis supressor .
The Uses of 2-Thiophenesulfonyl chloride
2-Thiophenesulfonyl chloride has been used in the preparation of 2-((trans-2-phenyl cyclopropyl)sulfonyl)thiophene
Synthesis Reference(s)
The Journal of Organic Chemistry, 39, p. 3286, 1974 DOI: 10.1021/jo00936a030
General Description
Kinetics of reactions of 2-thiophenesulfonyl chloride with substituted anilines in methanol has been reported. Kinetics of solvolysis of 2-thiophenesulfonyl chloride in binary solvent mixtures has been studied.
Properties of 2-Thiophenesulfonyl chloride
| Melting point: | 30-32 °C(lit.) |
| Boiling point: | 130-132 °C14 mm Hg(lit.) |
| Density | 1.534 (estimate) |
| refractive index | 1.5722-1.5742 |
| Flash point: | >110°C |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | soluble in Chloroform, Ethyl Acetate |
| form | solid |
| color | White to Almost white |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| BRN | 123536 |
| Stability: | Moisture sensitive |
| CAS DataBase Reference | 16629-19-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Thiophene sulfonyl chloride(16629-19-9) |
| EPA Substance Registry System | 2-Thiophenesulfonyl chloride (16629-19-9) |
Safety information for 2-Thiophenesulfonyl chloride
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Thiophenesulfonyl chloride
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