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HomeProduct name list2-Thiopheneacetyl chloride

2-Thiopheneacetyl chloride

Synonym(s):2-Thienylacetyl chloride

  • CAS NO.:39098-97-0
  • Empirical Formula: C6H5ClOS
  • Molecular Weight: 160.62
  • MDL number: MFCD00005456
  • EINECS: 254-290-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 16:49:49
2-Thiopheneacetyl chloride Structural

What is 2-Thiopheneacetyl chloride?

Description

2-Thiopheneacetyl chloride is used as a reagent to synthesize diamide derivatives of (S)-BINOL. These derivatives display potential anti-inflammatory and anti-arthritis effects. 2-Thiopheneacetyl chloride is also used in the synthesis of Nitrocefin (N493815), a chromogenic substrate that changes colour in the presence of β-lactamases and penicillin-binding proteins.

Chemical properties

CLEAR BROWN LIQUID

The Uses of 2-Thiopheneacetyl chloride

2-Thiopheneacetyl chloride was used in the synthesis of (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator, 5-fluorouracil-cephalosporin prodrug, series of new N,N?-di(thiopheneacetyl)diamines derivatives and 6-β-(thiophen-2?-yl)acetamidomorphine. Also used in the synthesis of Nitrocefin.

The Uses of 2-Thiopheneacetyl chloride

2-Thiopheneacetyl chloride was used in the synthesis of:

  • (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate, nipecotate-containing immunopotentiator
  • 5-fluorouracil-cephalosporin prodrug
  • series of new N,N′-di(thiopheneacetyl)diamines derivatives
  • 6-β-(thiophen-2′-yl)acetamidomorphine

What are the applications of Application

2-Thiopheneacetyl chloride is a useful chemical for the synthesis of many chemicals

General Description

A clear yellow to dark brown liquid. Insoluble in water and denser than water. Corrosive to skin, and eyes. Vapors severely irritate respiratory tract.

Air & Water Reactions

Insoluble in water. Decomposes exothermically in water yielding fumes of toxic hydrogen chloride.

Reactivity Profile

THIOPHENE-2-ACETYL CHLORIDE is incompatible with water, bases (including amines), with strong oxidizing agents, and with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Synthesis

In the four-hole boiling flask with mechanical stirring, thermometer, air guide outlet, add 100g 2-thiophene acetic acid; 350g methylene dichloride, stirs and is warming up to 37 DEG C, starts to drip 250g sulfur oxychloride under the protection of nitrogen; within 1.5 hours, drip off insulation reaction 2.5 hours at this temperature.The methylene dichloride of underpressure distillation remnants, continues to distill obtaining 2-thiophen acetyl chloride 102.5g, and yield reaches 91.5%.

Properties of 2-Thiopheneacetyl chloride

Boiling point: 105-106 °C/22 mmHg (lit.) 130-135 °C/90 mmHg (lit.)
Density  1.303 g/mL at 25 °C (lit.)
vapor pressure  4 mm Hg ( 83 °C)
refractive index  n20/D 1.551(lit.)
Flash point: 215 °F
storage temp.  2-8°C
form  Liquid
color  Clear brown
Specific Gravity 1.303
Water Solubility  Reacts with water.
Sensitive  Moisture Sensitive
BRN  114547
CAS DataBase Reference 39098-97-0(CAS DataBase Reference)
EPA Substance Registry System 2-Thiopheneacetyl chloride (39098-97-0)

Safety information for 2-Thiopheneacetyl chloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P363:Wash contaminated clothing before reuse.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 2-Thiopheneacetyl chloride

InChIKey AJYXPNIENRLELY-UHFFFAOYSA-N

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