2-Thiopheneacetic acid

Synonym(s):2-Thienylacetic acid

CAS NO.：1918-77-0
Empirical Formula: C6H6O2S
Molecular Weight: 142.18
MDL number: MFCD00005458
EINECS: 217-639-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:57

What is 2-Thiopheneacetic acid?

Chemical properties

white to light yellow crystal powder

The Uses of 2-Thiopheneacetic acid

2-Thiopheneacetic acid is used in the preparation of rosette-like nanoscale gold materials. Further, it is used as a pharmaceutical intermediate for cefaloridine and cefalotin sodium.

Definition

ChEBI: 2-thienylacetic acid is a thiophene compound having a carboxymethyl group at the 2-position. It has a role as an allergen. It is a member of thiophenes and a monocarboxylic acid. It is functionally related to an acetic acid. It is a conjugate acid of a thien-2-ylacetate.

Synthesis Reference(s)

Canadian Journal of Chemistry, 46, p. 1057, 1968 DOI: 10.1139/v68-179
Journal of the American Chemical Society, 72, p. 4326, 1950

General Description

Adsorption of 2-thiopheneacetic acid on XAD-4, NDA-100 and ND-90 resin has been investigated. A new polymeric complex of Cu(II) and 2-thiopheneacetic acid has been synthesized and characterized by IR and Raman spectroscopy.

Purification Methods

Crystallise the acid from ligroin, hexane and/or distil it in a vacuum. The amide has m 148o (from H2O or pet ether). [Beilstein 18 H 293, 18 III/IV 4062, 18/6 V 207.]

Properties of 2-Thiopheneacetic acid

Melting point:	63-64 °C (lit.)
Boiling point:	160 °C/22 mmHg (lit.)
Density	1.365 (estimate)
refractive index	1.5300 (estimate)
Flash point:	160°C/22mm
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
pka	4.23±0.10(Predicted)
form	Crystalline Powder
color	Slightly brown to brown
Water Solubility	Soluble in water, ethanol, ether and carbon tetrachloride.
BRN	114551
CAS DataBase Reference	1918-77-0(CAS DataBase Reference)
NIST Chemistry Reference	2-Thiopheneacetic acid(1918-77-0)
EPA Substance Registry System	2-Thiopheneacetic acid (1918-77-0)

Safety information for 2-Thiopheneacetic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.