2-Thiophenecarboxylic acid
- CAS NO.:527-72-0
- Empirical Formula: C5H4O2S
- Molecular Weight: 128.15
- MDL number: MFCD00005437
- EINECS: 208-423-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 18:52:02
What is 2-Thiophenecarboxylic acid?
Chemical properties
The substance is a light yellow crystal powder. It dissolves in hot water, ethanol, and ether, and is only slightly soluble in chloroform.
The Uses of 2-Thiophenecarboxylic acid
2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
Definition
ChEBI: Thiophene-2-carboxylic acid is a thiophenecarboxylic acid in which the carboxy group is located at position 2. It is a conjugate acid of a thiophene-2-carboxylate.
Production Methods
Thiophene 2-Carboxylic Acid, T2CA, is prepared via oxidation of 2-acetylthiophene using hypochlorite, because oxidation of alkylthiophenes leads to general breakdown of the thiophene ring.
What are the applications of Application
The sodium salt of 2-Thiophenecarboxylic acid(T2CA) is used to treat influenza (trophires). Other salts, e.g., the Li salt, have minor medicinal uses and the free acid is a mucolytic. A US Patent describes the use of the Na salt as a lubricating oil thickener. ?Suprofen, a nonsteroidal anti-inflammatory (NSAI), and tienilic acid (ticrynafen), a potent diuretic, were both very large prospective markets for T2CA or its acid chloride, but were almost completely withdrawn in the 1980s. Sanofi Aventis'NSAI tiaprofenic acid was comparatively successful in this market, but although it is still marketed it has subsequently been superceded by alternative products. The 5-nitro derivative of T2CA is used to produce nifurzide, an intestinal antibacterial. Pfizer's anti-inflammatory tenidap is a developing drug which uses the acid chloride of T2CA as the starting intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055
Purification Methods
Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]
Properties of 2-Thiophenecarboxylic acid
Melting point: | 125-127 °C(lit.) |
Boiling point: | 260 °C(lit.) |
Density | 1.42 |
refractive index | 1.5160 (estimate) |
Flash point: | 259-261°C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Acetone (Slightly), Chloroform (Slightly) |
form | solid |
pka | 3.49(at 25℃) |
color | White to Off-White |
Water Solubility | 80 g/L (20 ºC) |
Merck | 14,9354 |
BRN | 110150 |
CAS DataBase Reference | 527-72-0(CAS DataBase Reference) |
NIST Chemistry Reference | 2-Thiophenecarboxylic acid(527-72-0) |
EPA Substance Registry System | 2-Thiophenecarboxylic acid (527-72-0) |
Safety information for 2-Thiophenecarboxylic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 2-Thiophenecarboxylic acid
InChIKey | QERYCTSHXKAMIS-UHFFFAOYSA-N |
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