2-Pyrazinecarboxylic acid

Synonym(s):Pyrazinecarboxylic acid;Pyrazinoic acid

CAS NO.：98-97-5
Empirical Formula: C5H4N2O2
Molecular Weight: 124.1
MDL number: MFCD00006130
EINECS: 202-718-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 13:32:20

What is 2-Pyrazinecarboxylic acid?

Chemical properties

WHITE TO OFF-WHITE CRYSTALLINE POWDER

The Uses of 2-Pyrazinecarboxylic acid

Labelled analogue of Pyrazinecarboxylic Acid, a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).

The Uses of 2-Pyrazinecarboxylic acid

Pyrazinecarboxylic Acid is a very potent urate retaining drug. Pyrazinecarboxylic Acid is a metabolite of the antibacterial agent Pyrazinamide (P840600).

Definition

ChEBI: The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.

Synthesis Reference(s)

The Journal of Organic Chemistry, 40, p. 1187, 1975 DOI: 10.1021/jo00896a050

Flammability and Explosibility

Not classified

Purification Methods

It crystallises from water. The methyl ester has m 62o (from pet ether). [Sauville & Spoerri J Am Chem Soc 63 3153 1941, Beilstein 25 III/IV 771.]

Properties of 2-Pyrazinecarboxylic acid

Melting point:	222-225 °C (dec.)(lit.)
Boiling point:	230.85°C (rough estimate)
Density	1.4317 (rough estimate)
vapor pressure	0.011Pa at 25℃
refractive index	1.4800 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Crystalline Powder
pka	pK (25°) 2.92
color	White to off-white
Water Solubility	SOLUBLE IN COLD WATER
Merck	14,8970
BRN	112305
CAS DataBase Reference	98-97-5(CAS DataBase Reference)
NIST Chemistry Reference	Pyrazinoic acid(98-97-5)

Safety information for 2-Pyrazinecarboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.