2'-O-Methyluridine

CAS NO.：2140-76-3
Empirical Formula: C10H14N2O6
Molecular Weight: 258.23
MDL number: MFCD00056054
EINECS: 2017-001-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-28 13:53:27

What is 2'-O-Methyluridine?

Description

2'-O-Methyluridine is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands.

Chemical properties

White Solid

The Uses of 2'-O-Methyluridine

Uridine analog. 2'-O-Methyluridine is used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

The Uses of 2'-O-Methyluridine

Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.

What are the applications of Application

2′-O-Methyl Uridine is used for the preparation of antiviral nucleoside derivatives

Definition

ChEBI: A methyluridine that consists of uridine bearing a single methyl substituent located at position O-2' on the ribose ring.

Properties of 2'-O-Methyluridine

Melting point:	154-156°C
Density	1.53±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	9.39±0.10(Predicted)
form	Powder
color	White to Off-white
λmax	261nm(MeOH)(lit.)
CAS DataBase Reference	2140-76-3(CAS DataBase Reference)

Safety information for 2'-O-Methyluridine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H311:Acute toxicity,dermal H331:Acute toxicity,inhalation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician. P330:Rinse mouth. P361:Remove/Take off immediately all contaminated clothing. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…