5-Methyluridine
Synonym(s):Ribothymidine
- CAS NO.：1463-10-1
- Empirical Formula: C10H14N2O6
- Molecular Weight: 258.23
- MDL number: MFCD00006535
- EINECS: 215-973-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 08:26:49
What is 5-Methyluridine?
Description
5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.
Chemical properties
White Powder
The Uses of 5-Methyluridine
A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.
Definition
ChEBI: Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as a human metabolite, an Escherichia coli metabolite and an antigen.
Properties of 5-Methyluridine
| Melting point: | 183-184 °C(lit.) |
| Density | 1.576±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated) |
| pka | 9.55±0.10(Predicted) |
| form | powder |
| color | white |
| InChI | InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1 |
| CAS DataBase Reference | 1463-10-1(CAS DataBase Reference) |
Safety information for 5-Methyluridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Methyluridine
| InChIKey | DWRXFEITVBNRMK-JXOAFFINSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O |
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![5-METHYL-[1'-13C]URIDINE](https://img.chemicalbook.in/CAS/GIF/201996-60-3.gif)
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