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HomeProduct name list5-Methyluridine

5-Methyluridine

Synonym(s):Ribothymidine

  • CAS NO.:1463-10-1
  • Empirical Formula: C10H14N2O6
  • Molecular Weight: 258.23
  • MDL number: MFCD00006535
  • EINECS: 215-973-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
5-Methyluridine Structural

What is 5-Methyluridine?

Description

5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.

Chemical properties

White Powder

The Uses of 5-Methyluridine

A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.

Definition

ChEBI: Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as a human metabolite, an Escherichia coli metabolite and an antigen.

Properties of 5-Methyluridine

Melting point: 183-184 °C(lit.)
Density  1.576±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated)
pka 9.55±0.10(Predicted)
form  powder
color  white
InChI InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1
CAS DataBase Reference 1463-10-1(CAS DataBase Reference)

Safety information for 5-Methyluridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Methyluridine

InChIKey DWRXFEITVBNRMK-JXOAFFINSA-N
SMILES OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O

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