Doxifluridine
Synonym(s):5′dFUrd;5-Fluoro-5′-deoxyuridine;Doxifluridine
- CAS NO.:3094-09-5
- Empirical Formula: C9H11FN2O5
- Molecular Weight: 246.19
- MDL number: MFCD00866530
- EINECS: 221-440-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-05 12:01:54
What is Doxifluridine?
Description
Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemical properties
White Solid
Originator
Hoffmann-LaRoche (USA)
The Uses of Doxifluridine
A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
The Uses of Doxifluridine
An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
The Uses of Doxifluridine
5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
The Uses of Doxifluridine
antineoplastic, pyrimidine antimetabolite
What are the applications of Application
Doxifluridine is a fluorinated pyrimidine with cytostatic activity
Definition
ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
brand name
Furtulon
Biochem/physiol Actions
Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.
Properties of Doxifluridine
Melting point: | 188-192 °C(lit.) |
alpha | D25 +18.4° (c = 0.419 in water) |
Density | 1.3751 (estimate) |
refractive index | 20 ° (C=1, H2O) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 7.4(at 25℃) |
color | White |
Merck | 14,3437 |
CAS DataBase Reference | 3094-09-5(CAS DataBase Reference) |
Safety information for Doxifluridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to..… |
Computed Descriptors for Doxifluridine
Abamectin manufacturer
Aavyan Labs
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