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HomeProduct name list2'-O-Methylcytidine

2'-O-Methylcytidine

  • CAS NO.:2140-72-9
  • Empirical Formula: C10H15N3O5
  • Molecular Weight: 257.24
  • MDL number: MFCD11519076
  • EINECS: 2017-001-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-28 13:53:27
2'-O-Methylcytidine Structural

What is 2'-O-Methylcytidine?

Description

2'-O-Methylcytidine is a nucleoside with a hydroxyl group on the 2' carbon, making it an effective viral replication inhibitor. 2'-O-Methylcytidine is also metabolized by nucleotide salvage pathways and may be able to bind to the response element on DNA, which could inhibit protein synthesis in cancer cells. It is an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50 = 3.8 μM). It inhibits HCV replication in a replicon assay (IC50 = 21.2 μM).

Chemical properties

White powder

The Uses of 2'-O-Methylcytidine

2'-O-Methylcytidine is used in the preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

The Uses of 2'-O-Methylcytidine

Cytidine analog.

What are the applications of Application

2′-O-Methylcytidine is a cytidine analog

Definition

ChEBI: 2'-O-methylcytidine is a methylcytidine.

Properties of 2'-O-Methylcytidine

Melting point: 252-253 C
Boiling point: 506.0±60.0 °C(Predicted)
Density  1.68±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility  Soluble in DMSO.
form  Powder
pka 13.37±0.70(Predicted)
color  White to Off-white
InChI InChI=1S/C10H15N3O5/c1-17-8-7(15)5(4-14)18-9(8)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1
CAS DataBase Reference 2140-72-9(CAS DataBase Reference)

Safety information for 2'-O-Methylcytidine

Computed Descriptors for 2'-O-Methylcytidine

InChIKey RFCQJGFZUQFYRF-ZOQUXTDFSA-N
SMILES OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OC)[C@@H]1O

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