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HomeProduct name list2-Naphthalenesulfonyl chloride

2-Naphthalenesulfonyl chloride

  • CAS NO.:93-11-8
  • Empirical Formula: C10H7ClO2S
  • Molecular Weight: 226.68
  • MDL number: MFCD00004087
  • EINECS: 202-219-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:08:57
2-Naphthalenesulfonyl chloride Structural

What is 2-Naphthalenesulfonyl chloride?

Chemical properties

LIGHT YELLOW TO BEIGE POWDER

The Uses of 2-Naphthalenesulfonyl chloride

2-Naphthalenesulfonyl chloride was employed as capping reagent for primary amine to convert histamine to a selective histamine H3-receptor antagonist. It was used for pre-column derivatization during the high-performance liquid chromatographic assay of neomycin sulfate.

Flammability and Explosibility

Not classified

Purification Methods

Distil the chloride in a vacuum and/or recrystallise it (twice) from *benzene/pet ether (1:1 v/v). Purify it as the 1-sulfonyl chloride above. [Fierz-Davaid & Weissenbach Helv Chim Acta 3 2312 1920.] The sulfonamide has m 217o (from EtOH). [Beilstein 11 III 399, 11 IV 529.]

Properties of 2-Naphthalenesulfonyl chloride

Melting point: 74-76 °C (lit.)
Boiling point: 147.7 °C/0.6 mmHg (lit.)
Density  1.3661 (estimate)
vapor pressure  0.004Pa at 25℃
Flash point: 200-202°C/13mm
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  soluble in Toluene
form  Powder
color  Light yellow to beige
Water Solubility  insoluble
Sensitive  Moisture Sensitive
BRN  641898
CAS DataBase Reference 93-11-8(CAS DataBase Reference)
NIST Chemistry Reference 2-Naphthalenesulfonyl chloride(93-11-8)
EPA Substance Registry System 2-Naphthalenesulfonyl chloride (93-11-8)

Safety information for 2-Naphthalenesulfonyl chloride

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H290:Corrosive to Metals
H314:Skin corrosion/irritation
Precautionary Statement Codes P234:Keep only in original container.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 2-Naphthalenesulfonyl chloride

InChIKey OPECTNGATDYLSS-UHFFFAOYSA-N

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