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HomeProduct name list2-Ketoglutaric acid

2-Ketoglutaric acid

Synonym(s):2-Ketoglutaric acid;2-Oxoglutaric acid;2-Oxopentanedioic acid;alpha-Ketoglutarate;alpha-Ketoglutaric acid

  • CAS NO.:328-50-7
  • Empirical Formula: C5H6O5
  • Molecular Weight: 146.1
  • MDL number: MFCD00004165
  • EINECS: 206-330-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-25 09:45:49
2-Ketoglutaric acid Structural Picture

What is 2-Ketoglutaric acid?

Description

2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.

The Uses of 2-Ketoglutaric acid

2-Ketoglutaric acid has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries. It is used as an intermediate in the kreb's cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. It is also used in dietary supplements to improve protein synthesis.

What are the applications of Application

α-Ketoglutaric Acid is a derivative of glutaric acid

Properties of 2-Ketoglutaric acid

Melting point: 113-115 °C
Boiling point: 185.67°C (rough estimate)
Density  1.2821 (rough estimate)
storage temp.  2-8°C
solubility  H2O: soluble0.1g/mL, clear, colorless
form  Crystalline Powder
color  White to slightly yellow
Odor Odorless
Water Solubility  Soluble in water, methanol and dimethyl sulfoxide.

Safety information for 2-Ketoglutaric acid

Signal word Danger
Pictogram(s)

Corrosion
Corrosives
GHS05
GHS Hazard Statements H318:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 2-Ketoglutaric acid

InChIKey KPGXRSRHYNQIFN-UHFFFAOYSA-N

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