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HomeProduct name list2'-Fluoro-2'-deoxyuridine

2'-Fluoro-2'-deoxyuridine

  • CAS NO.:784-71-4
  • Empirical Formula: C9H11FN2O5
  • Molecular Weight: 246.19
  • MDL number: MFCD01317293
  • EINECS: 1806241-263-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
2'-Fluoro-2'-deoxyuridine Structural

What is 2'-Fluoro-2'-deoxyuridine?

Description

2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.

Chemical properties

White to almost white crystalline powder

The Uses of 2'-Fluoro-2'-deoxyuridine

2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

The Uses of 2'-Fluoro-2'-deoxyuridine

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Properties of 2'-Fluoro-2'-deoxyuridine

Melting point: 147.0 to 153.0 °C
Density  1.63±0.1 g/cm3(Predicted)
refractive index  53 ° (C=0.3, H2O)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  Soluble in methanol.
pka 9.39±0.10(Predicted)
form  Powder
color  White to Off-white
InChI InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
CAS DataBase Reference 784-71-4(CAS DataBase Reference)

Safety information for 2'-Fluoro-2'-deoxyuridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.

Computed Descriptors for 2'-Fluoro-2'-deoxyuridine

InChIKey UIYWFOZZIZEEKJ-XVFCMESISA-N
SMILES OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O

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