2'-Fluoro-2'-deoxyuridine
- CAS NO.：784-71-4
- Empirical Formula: C9H11FN2O5
- Molecular Weight: 246.19
- MDL number: MFCD01317293
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-11 20:10:50
What is 2'-Fluoro-2'-deoxyuridine?
Description
2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.
Chemical properties
White to almost white crystalline powder
The Uses of 2'-Fluoro-2'-deoxyuridine
2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
The Uses of 2'-Fluoro-2'-deoxyuridine
A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
Properties of 2'-Fluoro-2'-deoxyuridine
| Melting point: | 147.0 to 153.0 °C |
| Density | 1.63±0.1 g/cm3(Predicted) |
| refractive index | 53 ° (C=0.3, H2O) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in methanol. |
| pka | 9.39±0.10(Predicted) |
| form | Powder |
| color | White to Off-white |
| InChI | InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1 |
| CAS DataBase Reference | 784-71-4(CAS DataBase Reference) |
Safety information for 2'-Fluoro-2'-deoxyuridine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for 2'-Fluoro-2'-deoxyuridine
| InChIKey | UIYWFOZZIZEEKJ-XVFCMESISA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O |
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