2'-Deoxycytidine

Synonym(s):Cytosine deoxyriboside

CAS NO.：207121-53-7
Empirical Formula: C9H15N3O5
Molecular Weight: 245.24
MDL number: MFCD00006547
EINECS: 213-454-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:35

What is 2'-Deoxycytidine?

The Uses of 2'-Deoxycytidine

A deoxyribonucleoside as Eg5 kinesin modulator with antiproliferative and apoptosis-inducing activity.

Definition

ChEBI: 2'-deoxycytidine is a pyrimidine 2'-deoxyribonucleoside having cytosine as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a cytosine.

Purification Methods

Purify 2'-deoxycytidine by recrystallisation from MeOH/Et2O or EtOH and dry it in air. [NMR: Miles J Am Chem Soc 85 1007 1963, UV: Fox & Shugar Biochim Biophys Acta 9 369 1952.] The hydrochloride crystallises from H2O/EtOH and has m 174o(dec, 169-173o). [Walker & Butler Can J Chem 34 1168 1956.] The picrate has m 208o(dec). [Fox et al. J Am Chem Soc 83 4066 1961, Beilstein 25 III/IV 3662.]

Properties of 2'-Deoxycytidine

Melting point:	209-211 °C(lit.)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Methanol (Slightly), Water (Slightly)
form	Solid
color	White
Stability:	Hygroscopic
InChI	InChI=1/C9H13N3O4.H2O/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8;/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15);1H2/t5-,6+,8+;/s3

Safety information for 2'-Deoxycytidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.