2-Chloropyrimidine

CAS NO.：1722-12-9
Empirical Formula: C4H3ClN2
Molecular Weight: 114.53
MDL number: MFCD00006060
EINECS: 217-020-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 2-Chloropyrimidine?

Chemical properties

yellowish to pale orange crystals or cryst. powder

The Uses of 2-Chloropyrimidine

2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.

The Uses of 2-Chloropyrimidine

2-Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds. It was used in the synthesis of 4?-(1,1?-(5-(2-methoxyphenoxy)-[2,2?-bipyrimidine]-4,6-diyl)bis(1H-pyrazol-3,1-diyl)) dianiline fluorescent dye, biosensor for protein assay, 2-amino-4-heteroarylpyrimidines, cis- and trans-octahydropyrrolo[2,3]pyridine derivatives.

General Description

2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.

Purification Methods

It has been recrystallised from *C6H6, pet ether or a mixture of both. It sublimes at 50o/18mm and can be distilled in a vacuum. [IR: Short & Thompson J Chem Soc 168 1952, Boarland & McOmie J Chem Soc 1218 1951, Beilstein 23/5 V 343.]

Properties of 2-Chloropyrimidine

Melting point:	63-66 °C (lit.)
Boiling point:	75-76 °C/10 mmHg (lit.)
Density	1.2710 (rough estimate)
refractive index	1.5320 (estimate)
Flash point:	98 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Methanol, Water
pka	-1.46±0.13(Predicted)
form	Crystals or Crystalline Powder
color	Yellow to pale orange
Water Solubility	Slightly soluble in water. 33.3 mg soluble in 1 mL of alcohol.
Sensitive	Moisture Sensitive
BRN	107171
CAS DataBase Reference	1722-12-9(CAS DataBase Reference)
NIST Chemistry Reference	Pyrimidine, 2-chloro-(1722-12-9)

Safety information for 2-Chloropyrimidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.