2-Chloroethyl chloroformate

Synonym(s):2-Chloroethoxycarbonyl chloride

CAS NO.：627-11-2
Empirical Formula: C3H4Cl2O2
Molecular Weight: 142.97
MDL number: MFCD00000646
EINECS: 210-982-4
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-06 16:20:44

What is 2-Chloroethyl chloroformate?

Chemical properties

Clear colorless liquid

The Uses of 2-Chloroethyl chloroformate

2-Chloroethyl Chloroformate is a reactant used in the preparation of artemisinin-derived dimer carbonates and thiocarbonates with antimalarial activity.

General Description

Liquid.

Air & Water Reactions

Decomposed slowly by water forming ethanol, HCl, and CO2; on contact with moist air, 2-Chloroethyl chloroformate gives off HCl fumes; attacks many metals especially in humid atmosphere. REF [Handling Chemicals Safely, 1980. p. 476].

Reactivity Profile

2-Chloroethyl chloroformate is an acid halide. Acid halides are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

(Non-Specific -- Ethyl Chloroformate) Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes.

Safety Profile

Poison by inhalation. May also cause fatahties by ingestion or skin contact. May cause burns to the eyes and skin. When heated to decomposition it emits toxic fumes of Cl-

Purification Methods

Purify it by fractional distillation, preferably in a vacuum and store it in a dry atmosphere. [Jones J Chem Soc 2735 1957, Beilstein 3 IV 24.]

Properties of 2-Chloroethyl chloroformate

Melting point:	<25 °C
Boiling point:	155-156°C
Density	1.385
vapor pressure	0.23 psi ( 20 °C)
refractive index	1.446
Flash point:	158°F
storage temp.	Inert atmosphere,2-8°C
solubility	soluble in Ether,Benzene,Acetone
form	Liquid
color	Colorless to yellow
BRN	506639
CAS DataBase Reference	627-11-2(CAS DataBase Reference)
NIST Chemistry Reference	Carbonochloridic acid, 2-chloroethyl ester(627-11-2)
EPA Substance Registry System	2-Chloroethyl chloroformate (627-11-2)

Safety information for 2-Chloroethyl chloroformate

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H314:Skin corrosion/irritation H331:Acute toxicity,inhalation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.