2-Chloro-5-nitronicotinic acid

CAS NO.：42959-38-6
Empirical Formula: C6H3ClN2O4
Molecular Weight: 202.55
MDL number: MFCD06658402
EINECS: 214-589-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-24 18:12:00

What is 2-Chloro-5-nitronicotinic acid?

Synthesis

2-Hydroxy-5-nitro-nicotinic acid (2.7 mmol) in a mixture of NJV- dimethylformamide (2.7 mmol) and thionyl chloride (5 ml) was heated at 80 0C for 1 h. The mixture was allowed to cool and concentrated in a vacuum. To the resulting residue, ice water (20 ml) was added, and with vigorous stirring, a precipitate formed. The precipitate was filtered off and dried in a vacuum oven to give a white solid 2-Chloro-5-nitronicotinic acid (68 percent).

Properties of 2-Chloro-5-nitronicotinic acid

Melting point:	140-143℃
Boiling point:	384.8±42.0 °C(Predicted)
Density	1.702±0.06 g/cm3(Predicted)
pka	1.57±0.10(Predicted)
form	Solid
color	White to yellow
Sensitive	Moisture Sensitive
CAS DataBase Reference	42959-38-6(CAS DataBase Reference)

Safety information for 2-Chloro-5-nitronicotinic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.