4-Nitrobenzyl chloride

Description

Benzene, 1-(chloromethyl)-4-nitro- is a crystalline solid. Molecular weight= 171.58; Freezing/Meltingpoint =71℃. Slightly soluble in water; slow reaction.

Chemical properties

white to light yellow crystal powde

Chemical properties

Benzene, 1-(chloromethyl)-4-nitro-, is a crystalline solid.

The Uses of 4-Nitrobenzyl chloride

4-Nitrobenzyl chloride was used to prepare unsymmetrically N,N′-bis(substituted) 4,13-diaza-18-crown-6-ether derivatives.

What are the applications of Application

4-Nitrobenzyl chloride is a GST Substrate

Definition

ChEBI: A C-nitro compound that is nitrobenzene in which the hydrogen at position 4 is replaced by a chloromethyl group.

Production Methods

Chlorination of 4-nitrotoluene at 190 ℃ without catalyst gives 4-Nitrobenzyl chloride. The alternative process of nitration of benzylchloride coproduces 2-nitrobenzyl chloride and requires a difficult separation stage.

General Description

Solid.

Air & Water Reactions

May react slowly with water.

Reactivity Profile

Incompatible with sodium hydroxide. [EPA, 1998]. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Health Hazard

Poisonous if swallowed or dust is inhaled.

Fire Hazard

Incompatible with sodium hydroxide.

Potential Exposure

A chloronitrobenzene compound, used in organic synthesis.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Store in a refrigerator or in acool, dry place and protect from prolonged exposure tomoisture.

Shipping

UN3261 Corrosive solid, acidic, organic, n.o.s., Hazard class: 8; Labels: 8—Corrosive material, Technical Name Required. UN1578 Chloronitrobenzenes, solid or liquid, Hazard Class: 6.1; Labels: 6.1—Poisonous materials.

Purification Methods

Crystallise the chloride from CCl4, dry diethyl ether, or n-heptane, and dry it under vacuum. IRRITANT.[Beilstein 5 IV 856.]

Incompatibilities

Can react with sulfuric acid. Keep away from oxidizers, amines, bases: sodium hydroxide, and potassium hydroxide; may cause fire and explosions. Incompatible with strong oxidizing and reducing agents such as hydrides, certain amines, nitrides, azo/diazo compounds, alkali metals (potassium), and epoxides. Corrodes steel, some plastics and human tissue.