2-Chloro-5-hydroxypyrimidine
- CAS NO.:4983-28-2
- Empirical Formula: C4H3ClN2O
- Molecular Weight: 130.53
- MDL number: MFCD09743796
- EINECS: 826-504-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-16 11:16:30
What is 2-Chloro-5-hydroxypyrimidine?
The Uses of 2-Chloro-5-hydroxypyrimidine
2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.
Synthesis
2-Chloro-5-methoxypyrimidine (0.46 g, 3.18 mmol) in methylene chloride (10 mL) was treated with 1.0 N boron tribromide (16 mL, 16 mmol) at room temperature. The solution was stirred overnight. After that, the reaction was partitioned between saturated NaHCO3 and DCM. The aqueous layer was extracted with additional DCM. Combined the organic layers and dried (MgSO4), filtered, and concentrated to obtain the crude product. The residue was purified by flash column chromatography on silica gel to give 2-Chloro-5-hydroxypyrimidine.
Properties of 2-Chloro-5-hydroxypyrimidine
Melting point: | 195-196 °C |
Boiling point: | 328.1±15.0 °C(Predicted) |
Density | 1.513±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
pka | 6.17±0.23(Predicted) |
CAS DataBase Reference | 4983-28-2(CAS DataBase Reference) |
Safety information for 2-Chloro-5-hydroxypyrimidine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 2-Chloro-5-hydroxypyrimidine
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