2-Chloro-4-methylaniline

Synonym(s):2-Chloro-p-toluidine;4-Amino-3-chlorotoluene

CAS NO.：615-65-6
Empirical Formula: C7H8ClN
Molecular Weight: 141.6
MDL number: MFCD00007666
EINECS: 210-440-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:31

What is 2-Chloro-4-methylaniline?

Chemical properties

clear yellow to pale brown liquid

Chemical properties

The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.

The Uses of 2-Chloro-4-methylaniline

2-Chloro-4-methylaniline is an intermediate used to prepare reverse transcriptase inhibitors of HIV-1.

The Uses of 2-Chloro-4-methylaniline

2-Chloro-4-methylaniline was used in determination of aniline derivatives in environmental water samples using on-line combination of supported liquid membrane extraction and liquid chromatography. It was also used in determination of amines in environmental water samples by gas chromatography–mass spectrometry.

Safety Profile

Poison by ingestion. A severe eye and skin irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of Cland NOx. See also other chloro toluidine entries.

Potential Exposure

Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.

Shipping

UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials

Incompatibilities

Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

Properties of 2-Chloro-4-methylaniline

Melting point:	7 °C (lit.)
Boiling point:	223-225 °C (lit.)
Density	1.151 g/mL at 25 °C (lit.)
refractive index	n20/D 1.575(lit.)
Flash point:	211 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	methanol: soluble
form	Liquid
pka	3.09±0.10(Predicted)
color	Clear yellow to pale brown
BRN	774514
Stability:	Acid Sensitive, Light Sensitive
CAS DataBase Reference	615-65-6(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 2-chloro-4-methyl-(615-65-6)
EPA Substance Registry System	Benzenamine, 2-chloro-4-methyl- (615-65-6)

Safety information for 2-Chloro-4-methylaniline

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H370:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure H373:Specific target organ toxicity, repeated exposure H402:Hazardous to the aquatic environment, acute hazard H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P307+P311:IF exposed: call a POISON CENTER or doctor/physician. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…