2-Bromoethanol
Synonym(s):Ethylene bromohydrin
- CAS NO.:540-51-2
- Empirical Formula: C2H5BrO
- Molecular Weight: 124.96
- MDL number: MFCD00002827
- EINECS: 208-748-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-02 10:06:57
What is 2-Bromoethanol?
Chemical properties
Colorless to dark brown liquid. Sweet burning taste.
Chemical properties
2-Bromoethanol is a colorless or light yellow hygroscopic liquid with relatively stable and toxic chemical properties. It plays a role in industrial and chemical experiments. It shall be stored in a ventilated, low-temperature and dry warehouse and separated from oxidants, acids and food additives. It is miscible with water and forms an azeotrope with water. The boiling point is 99.1 ℃ (101.35kpa). The aqueous solution has a sweet burning taste. It can be miscible with most organic solvents such as ethanol and ether, but insoluble in petroleum ether. The hydrolysis of aqueous solution can be accelerated when it meets acid, alkali and heating.
The Uses of 2-Bromoethanol
Ethylene bromohydrin is not used much forany commercial purpose. The risk of expo sure to this compound arises when ethyleneoxide reacts with hydrobromic acid.
The Uses of 2-Bromoethanol
2-Bromoethanol is utilized in selective reduction of nitroarenes. It is used as a solvent and organic synthetic raw material. It finds application in the synthesis of 2-piperidin-1-yl-ethanol by reacting with piperidine. It is used in selective reduction of nitroarenes.
Air & Water Reactions
Hygroscopic. Water soluble.
Reactivity Profile
2-Bromoethanol forms an azeotrope with water; hydrolysis of aqueous solutions is accelerated by heat, alkalis and acids.
Hazard
Irritant to eyes and mucous membranes.
Health Hazard
The vapors of ethylene bromohydrin are anirritant to the eyes and mucous membranes.It is corrosive to the skin. Ingestion of thiscompound can produce moderate to severetoxic effects. The target organs are the CNS,gastrointestinal tract, and liver. The lethaldose in mice by the intraperitoneal route was80 mg/kg.
Ethylene bromohydrin manifested car cinogenicity in test animals. It caused tumorsin lungs and the gastrointestinal tract in micefrom intraperitoneal (150 mg/kg/8 weeks)and oral (43 mg/kg/80 weeks) dosages,respectively. It is a mutagen, positive to thehistidine reversion–Ames test.
Fire Hazard
2-Bromoethanol is combustible.
Safety Profile
Poison by intraperitoneal route. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also
Waste Disposal
Ethylene bromohydrin is mixed with a combustible solvent and burned in a chemicalincinerator.
Properties of 2-Bromoethanol
Melting point: | -80 °C |
Boiling point: | 56-57 °C/20 mmHg (lit.) |
Density | 1.763 g/mL at 25 °C (lit.) |
vapor density | 4.3 (vs air) |
vapor pressure | 2.4 mm Hg ( 20 °C) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | 1-5 g/100 mL at 19°C |
form | Liquid |
pka | 13.82±0.10(Predicted) |
Specific Gravity | 1.7629 (20/4℃) |
color | Clear colorless to yellow |
Water Solubility | 1-5 g/100 mL at 19 ºC |
Sensitive | Light Sensitive |
Merck | 14,3792 |
BRN | 878140 |
Stability: | Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water. |
CAS DataBase Reference | 540-51-2(CAS DataBase Reference) |
NIST Chemistry Reference | Ethanol, 2-bromo-(540-51-2) |
EPA Substance Registry System | 2-Bromoethanol (540-51-2) |
Safety information for 2-Bromoethanol
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Bromoethanol
InChIKey | LDLCZOVUSADOIV-UHFFFAOYSA-N |
Abamectin manufacturer
JSK Chemicals
Covalent Incorporation
ALS INDIA LIFE SCIENCES
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