2-Bromo-4-(trifluoromethyl)pyridine

CAS NO.：175205-81-9
Empirical Formula: C6H3BrF3N
Molecular Weight: 225.99
MDL number: MFCD00153085
EINECS: 672-057-5
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 2-Bromo-4-(trifluoromethyl)pyridine?

The Uses of 2-Bromo-4-(trifluoromethyl)pyridine

2-Bromo-4-(trifluoromethyl)pyridine in used in the preparation of pyrazolopyridines as kinase LRRK2 inhibitors for treating and preventing cancer and neurodegenerative diseases.

The Uses of 2-Bromo-4-(trifluoromethyl)pyridine

Regioselective deprotonation at C-3 with LDA followed by trapping with carbon dioxide provides the correspondin nicotinic acid.

Properties of 2-Bromo-4-(trifluoromethyl)pyridine

Melting point:	-21--20 °C
Boiling point:	84-85 °C/14 mmHg
Density	1.827 g/mL at 25 °C
refractive index	n20/D 1.478
Flash point:	164 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	clear liquid
pka	-1.57±0.10(Predicted)
color	Colorless to Light yellow to Light orange
CAS DataBase Reference	175205-81-9(CAS DataBase Reference)

Safety information for 2-Bromo-4-(trifluoromethyl)pyridine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.