2-Bromo-4-methylpyridine

CAS NO.：4926-28-7
Empirical Formula: C6H6BrN
Molecular Weight: 172.02
MDL number: MFCD00082590
EINECS: 625-590-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 2-Bromo-4-methylpyridine?

Chemical properties

Colorless to orange oily liqui

The Uses of 2-Bromo-4-methylpyridine

2-Bromo-4-methylpyridine may be used:

in the total synthesis of ocular age pigment A2-E (2 equiv of retinal (vitamin A) and 1 equiv of ethanolamine)
in the preparation of methoxy-2-(2-pyridyl)indoles
in the preparation of 2-(2′,4′-difluorophenyl)-4-methylpyridine, via a Suzuki coupling reaction with 2,4-difluorophenylboronic acid

The Uses of 2-Bromo-4-methylpyridine

An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity

What are the applications of Application

2-Bromo-4-methylpyridine can be used as an intermediate in organic synthesis and medicinal chemistry, mostly in the structural modification and synthesis of drug molecules. In basic chemistry research, the substance can be used for the synthesis of a series of organic nitrogen ligands containing pyridine units, and has good applications in the basic research of methodology of transition metal catalysis.

Properties of 2-Bromo-4-methylpyridine

Boiling point:	87 °C/10 mmHg (lit.)
Density	1.545 g/mL at 25 °C (lit.)
refractive index	n20/D 1.561(lit.)
Flash point:	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol (Slightly)
form	Liquid
pka	1.46±0.10(Predicted)
Specific Gravity	1.545
color	Clear yellow
BRN	107331
InChI	InChI=1S/C6H6BrN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
CAS DataBase Reference	4926-28-7(CAS DataBase Reference)

Safety information for 2-Bromo-4-methylpyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.