2-AMINO-BETA-NAPHTHOTHIAZOLE

Synonym(s):Naphtho[1,2-d]thiazol-2-ylamine

CAS NO.：40172-65-4
Empirical Formula: C11H8N2S
Molecular Weight: 200.26
MDL number: MFCD00051329
EINECS: 254-822-1
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is 2-AMINO-BETA-NAPHTHOTHIAZOLE?

Description

SKA-31 (40172-65-4) is a KCa3.1 and KCa2 potassium channel activator (EC50 =260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively). Enhanced acetylcholine-induced EDHF dilator response in mouse carotid arteries and lowers blood pressure in mouse models at 30 mg/Kg.1,2 Evokes robust vasodilation in rat mesenteric arteries.3

Biological Activity

Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

storage

+4°C

References

Sankaranaravanan et al. (2009), Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure; Mol. Pharmacol., 75 281 Brahler et al. (2009), Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator and causes hypertension ; Circulation, 119 2323 Khaddaj-Mallat al. (2018), SKA-31, an activator of endothelial Ca2+-activated K+ channels evokes robust vasodilation in rat mesenteric arteries; Eur. J. Pharmacol., 831 60

Properties of 2-AMINO-BETA-NAPHTHOTHIAZOLE

Melting point:	184-188°C
Boiling point:	417.1±28.0 °C(Predicted)
Density	1.403±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: ≥30mg/mL
form	solid
pka	3.50±0.30(Predicted)
color	Off-white
Stability:	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
CAS DataBase Reference	40172-65-4(CAS DataBase Reference)
EPA Substance Registry System	Naphtho[1,2-d]thiazol-2-amine (40172-65-4)

Safety information for 2-AMINO-BETA-NAPHTHOTHIAZOLE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention.