NOTUMib-1
- Molecular Weight: 0
- Update Date: 2023-04-23 13:52:06
What is NOTUMib-1?
Description
NOTUM is a carboxylesterase which depalmitoylates Wnt proteins which results in disruption of Wnt signaling.1?NOTUMib-1 inhibits the carboxylesterase activity of NOTUM, IC50=0.085 μM, and restores Wnt signaling. An important new tool for use in cellular disease models in which overactivity of NOTUM suppresses Wnt activity.2?NOTUM inhibitors have potential as new therapeutics for degenerative diseases.3
The Uses of NOTUMib-1
NOTUMib-1 is a NOTUM inhibitor. NOTUM inhibitors have potentials as new therapeutics for degenerative diseases.
References
1) Zhang?et al.?(2016),?Methods for Studying Wnt Protein Modifications/Inactivations by Extracellular Enzymes Tiki and Notum; Methods Mol. Biol.,?1481?29 2) Atkinson?et al.?(2019),?Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen; Med. Chem. Commun.?10?1361 3) Suciu?et al.?(2018),?Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling; ACS Med. Chem. Lett.,?9?563
Properties of NOTUMib-1
storage temp. | -20° (des.) |
solubility | Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming). |
form | solid |
color | Beige |
Stability: | Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
Safety information for NOTUMib-1
Computed Descriptors for NOTUMib-1
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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