ML335
- CAS NO.：825658-06-8
- Empirical Formula: C15H14Cl2N2O3S
- Molecular Weight: 373.25
- MDL number: MFCD06003481
- Update Date: 2023-06-30 15:45:59
What is ML335?
Description
Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels.
The Uses of ML335
ML335, is a selective activator of both TREK-1 and TREK-2.
storage
Store at +4°C
References
1) Lolicato?et al.?(2017),?K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature,?547?364
Properties of ML335
| storage temp. | -20° |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming). |
| form | solid |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
Safety information for ML335
Computed Descriptors for ML335
New Products
Tubulysin C Tubulysin H Tubulysin I Tubulysin A Potassium HMDS (1.0 M in THF) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) CYCLOBUTYLAMINE HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Fuel shell Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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