15D-PGJ2
Synonym(s):11-Oxoprosta-(5Z,9,12E,14E)-tetraen-1-oic acid;15-Deoxy-Δ12,14-PGJ2;15d-PGJ₂ - CAS 87893-55-8 - Calbiochem;Prostaglandin J₂, 15-Deoxy-Δ 12,14, PPAR Agonist VII, PPARγ Agonist VI
- CAS NO.:87893-55-8
- Empirical Formula: C20H28O3
- Molecular Weight: 316.43
- MDL number: MFCD00065806
- EINECS: 201-185-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is 15D-PGJ2?
The Uses of 15D-PGJ2
15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
What are the applications of Application
15-Deoxy-δ12,14-Prostaglandin J2 is an endogenous PPARγ ligand and ANKTM1 (TRPA1) agonist
What are the applications of Application
15-deoxy-Δ12,14-Prostaglandin J2 solution is an agonist of DP1/DP2 receptors and endogenous ligand for PPARγ
Definition
ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-).
General Description
A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.
Biological Activity
Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M).
Biochem/physiol Actions
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.
Properties of 15D-PGJ2
Flash point: | -9℃ |
storage temp. | -20°C |
solubility | Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml) |
form | methyl acetate solution |
color | Colorless to light yellow |
Safety information for 15D-PGJ2
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H225:Flammable liquids H319:Serious eye damage/eye irritation H336:Specific target organ toxicity,single exposure; Narcotic effects |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 15D-PGJ2
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