1,2,3,4-Tetrahydro-1-naphthol

Synonym(s):α-Tetralol

CAS NO.：529-33-9
Empirical Formula: C10H12O
Molecular Weight: 148.2
MDL number: MFCD00001739
EINECS: 208-459-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-23 19:22:53

1,2,3,4-Tetrahydro-1-naphthol Structural

What is 1,2,3,4-Tetrahydro-1-naphthol?

Chemical properties

clear colourless to slightly brown viscous liquid

The Uses of 1,2,3,4-Tetrahydro-1-naphthol

1,2,3,4-Tetrahydro-1-naphthol was used as chiral probe to examine the role of three aromatic residues in enzyme-substrate interactions at the sulfuryl acceptor binding site of aryl sulfotransferase IV enzyme.

Synthesis Reference(s)

The Journal of Organic Chemistry, 61, p. 1493, 1996 DOI: 10.1021/jo951219c

General Description

(R)-(-)-enantiomer of 1,2,3,4-Tetrahydro-1-naphthol is a substrate for aryl sulfotransferase (AST) IV enzyme and (S)-(+)-1,2,3,4-tetrahydro-1-naphthol is a competitive inhibitor of AST IV-catalyzed sulfation of 1-naphthalenemethanol. It is the major urinary metabolite of tetralin.

Properties of 1,2,3,4-Tetrahydro-1-naphthol

Melting point:	28-32 °C
Boiling point:	102-104 °C2 mm Hg(lit.)
Density	1.09 g/mL at 25 °C(lit.)
refractive index	n20/D 1.564(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	5.09g/l
form	powder to lump to clear liquid
pka	14.33±0.20(Predicted)
Specific Gravity	1.090
color	White or Colorless to Light yellow
BRN	2046227
CAS DataBase Reference	529-33-9(CAS DataBase Reference)
NIST Chemistry Reference	1-Naphthalenol, 1,2,3,4-tetrahydro-(529-33-9)
EPA Substance Registry System	1-Naphthalenol, 1,2,3,4-tetrahydro- (529-33-9)

Safety information for 1,2,3,4-Tetrahydro-1-naphthol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.