1,1,3-Trichloroacetone

Synonym(s):1,1,3-Trichloro-2-propanone;TCA

CAS NO.：921-03-9
Empirical Formula: C3H3Cl3O
Molecular Weight: 161.41
MDL number: MFCD00040500
EINECS: 213-063-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-26 21:18:56

What is 1,1,3-Trichloroacetone?

Description

1,1,3-Trichloroacetone is direct-acting mutagens in the Ames/Salmonella assay. It is precursor for the generation of 1,3-dihalo oxyallyl intermediates, which undergo [4 + 3] cycloadditions with a host of 1,3-diene systems.

Chemical properties

Light yellow transparent liquid

The Uses of 1,1,3-Trichloroacetone

1,1,3-Trichloroacetone was used in base-induced solvolyses of [3.2.1]Bicyclic α,α′-dichloro ketones.

The Uses of 1,1,3-Trichloroacetone

1,1,3-Trichloroacetone is a reagent used to synthesize chlorinated 5-hydroxy-4-methyl-2(5H)-furanones and mucochloric acid. In addition, it can also be used to synthesize (+)-Phorbol. Phorbol derivatives are important for biomedical research and capable of stimulating T-cell activation, proliferation and cytokine production.

Safety Profile

Poison by inhalation. Corrosiveand lachrymator. Mutation data reported. Combustibleliquid. When heated to decomposition it emits toxic fumesof Clí.

Properties of 1,1,3-Trichloroacetone

Melting point:	9-11 °C(lit.)
Boiling point:	88-90 °C76 mm Hg(lit.)
Density	1.512 g/mL at 20 °C(lit.)
vapor pressure	30-350Pa at 20-50℃
refractive index	n20/D 1.491
Flash point:	80
storage temp.	Refrigerator, under inert atmosphere
solubility	Chloroform, Methanol
form	Oil
color	Clear Colourless
BRN	1746647
CAS DataBase Reference	921-03-9(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanone, 1,1,3-trichloro-(921-03-9)

Safety information for 1,1,3-Trichloroacetone

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H314:Skin corrosion/irritation H330:Acute toxicity,inhalation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.