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HomeProduct name list1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Synonym(s):MET;Chlorobutanol;Chloretone;Hepatocyte growth factor receptor;HGF/SF receptor

  • CAS NO.:6001-64-5
  • Empirical Formula: C8H16Cl6O3
  • Molecular Weight: 372.93
  • MDL number: MFCD02179352
  • EINECS: 611-927-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-18 17:01:59
1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE Structural

What is 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE?

Chemical properties

white crystalline solid

The Uses of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Pharmaceutic aid (antimicrobial agent).

The Uses of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

The Uses of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate in combination with dimethyl sulfone, can serve as an appropriate solvent for the freeze drying of certain parenteral organic drugs, which have an increase in many factors such as stability, dissolution rate, dosing accuracy and sterility.

brand name

Chloretone (Parke-Davis).

General Description

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) converts benzisoxazole to α-aryloxyisobutyric acid. 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.

Biochem/physiol Actions

Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.

Properties of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Melting point: 77-79 °C(lit.)
Boiling point: 173-175 °C
Flash point: 100 °C
storage temp.  2-8°C
solubility  Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent).
form  Crystalline Powder, Crystals and/or Chunks
color  White to almost white
Water Solubility  Soluble in ethanol, ether, chloroform, and glycerol. Insoluble in water.
Merck  14,2129
BRN  878167
Stability: Stable. Generates toxic fumes on combustion. Incompatible with strong oxidizing agents.
CAS DataBase Reference 6001-64-5

Safety information for 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE

Abamectin manufacturer

AVD pharmaceuticals Pvt Ltd

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Technodrugs Intermediates Pvt. Ltd.

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Merck Ltd

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Rivashaa Agrotech Biopharma Pvt. Ltd.

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Atul Bioscience Ltd

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Laxachem Organics Pvt Ltd

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Vijaya Pharma And Life Science

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Navone Specialties (OPC) Pvt Ltd

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