1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Synonym(s):MET;Chlorobutanol;Chloretone;Hepatocyte growth factor receptor;HGF/SF receptor
- CAS NO.:6001-64-5
- Empirical Formula: C8H16Cl6O3
- Molecular Weight: 372.93
- MDL number: MFCD02179352
- EINECS: 611-927-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 18:52:02
What is 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE?
Chemical properties
white crystalline solid
The Uses of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate converts benzisoxazole to α-aryloxyisobutyric acid. It forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.
The Uses of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Pharmaceutic aid (antimicrobial agent).
The Uses of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate in combination with dimethyl sulfone, can serve as an appropriate solvent for the freeze drying of certain parenteral organic drugs, which have an increase in many factors such as stability, dissolution rate, dosing accuracy and sterility.
brand name
Chloretone (Parke-Davis).
General Description
1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) converts benzisoxazole to α-aryloxyisobutyric acid. 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) forms eutectic with dimethyl sulfone, which is the most suitable media for freeze-drying due to its high solubilizing ability and a good rate of solvent removal.
Biochem/physiol Actions
Chlorobutanol or 1,1,1-Trichloro-2-methyl-2-propanol is a opthalmic preservative and sedative hypnotic that possess antibacterial and antifungal properties. It also decreases the conduction velocity and induces conduction failure and automaticity within isolated ventricular muscle strips as well as impacts myocardial cells by acting on cell membrane and reduces isometric tension produced by heart.
Properties of 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Melting point: | 77-79 °C(lit.) |
Boiling point: | 173-175 °C |
Flash point: | 100 °C |
storage temp. | 2-8°C |
solubility | Slightly soluble in water, very soluble in ethanol (96 per cent), soluble in glycerol (85 per cent). |
form | Crystalline Powder, Crystals and/or Chunks |
color | White to almost white |
Water Solubility | Soluble in ethanol, ether, chloroform, and glycerol. Insoluble in water. |
Merck | 14,2129 |
BRN | 878167 |
Stability: | Stable. Generates toxic fumes on combustion. Incompatible with strong oxidizing agents. |
CAS DataBase Reference | 6001-64-5 |
Safety information for 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for 1,1,1-TRICHLORO-2-METHYL-2-PROPANOL HEMIHYDRATE
Abamectin manufacturer
AVD pharmaceuticals Pvt Ltd
Rivashaa Agrotech Biopharma Pvt. Ltd.
Laxachem Organics Pvt Ltd
Vijaya Pharma And Life Science
Navone Specialties (OPC) Pvt Ltd
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