1-Methoxynaphthalene
Synonym(s):Methyl 1-naphthyl ether;NSC 5530
- CAS NO.:2216-69-5
- Empirical Formula: C11H10O
- Molecular Weight: 158.2
- MDL number: MFCD00003924
- EINECS: 218-696-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 18:09:03
What is 1-Methoxynaphthalene?
Chemical properties
1-Methoxynaphthalene is an isomer of methoxynaphthalene. It is clear light yellow to brown liquid that aroma is not as good as 2-methoxynaphthalene. Insoluble in water, soluble in ethanol, ether, benzene and chloroform.
The Uses of 1-Methoxynaphthalene
1-Methoxynaphthalene is used in the study of peroxygenase activity of cytochrome c peroxidase. It is used as a precursor to synthesize prenyl naphthalene-ols, which shows antioxidative activity. It is also used in organic synthesis, pesticides, perfumes for making soaps, and film developers.
Preparation
1-Methoxynaphthalene can be obtained by methylating 1-naphthol, and the methylating reagent can be selected from methyl trifluoroacetate, dimethyl carbonate and dimethyl sulfate.
Synthesis Reference(s)
Tetrahedron Letters, 32, p. 675, 1991 DOI: 10.1016/S0040-4039(00)74857-X
General Description
1-Methoxynaphthalene, a methoxyphenolic compound, is a naphthalene derivative that finds application as a precursor for the preparation of pharmaceutical drugs, and also as a therapeutic agent.
Purification Methods
Steam distil the ether from alkaline solution. The distillate is extracted with Et2O. After drying (MgSO4) the extract and evaporating Et2O, the methyl naphthyl ether is then fractionated under reduced pressure from CaH2. The picrate has m 129.5-130.5o (from EtOH). [Beilstein 6 IV 4211.]
Properties of 1-Methoxynaphthalene
Melting point: | 5 °C |
Boiling point: | 135-137 °C/12 mmHg (lit.) |
Density | 1.09 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Chloroform, Methanol |
form | Oil |
color | Clear Colorless to Yellow |
Specific Gravity | 1.1 |
Water Solubility | immiscible |
BRN | 7748884 |
CAS DataBase Reference | 2216-69-5(CAS DataBase Reference) |
NIST Chemistry Reference | Naphthalene, 1-methoxy-(2216-69-5) |
EPA Substance Registry System | Naphthalene, 1-methoxy- (2216-69-5) |
Safety information for 1-Methoxynaphthalene
Computed Descriptors for 1-Methoxynaphthalene
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