1-METHOXY-4-NITRONAPHTHALENE
- CAS NO.:4900-63-4
- Empirical Formula: C11H9NO3
- Molecular Weight: 203.19
- MDL number: MFCD00003926
- EINECS: 225-528-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-11-11 11:01:00
What is 1-METHOXY-4-NITRONAPHTHALENE?
Chemical properties
yellow to orange crystalline powder
The Uses of 1-METHOXY-4-NITRONAPHTHALENE
1-Methoxy-4-nitronaphthalene is used as a reagent in the synthesis of UMI-77 (U700850); a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Also an anticancer agent.
Synthesis Reference(s)
Synthesis, p. 70, 1985 DOI: 10.1055/s-1985-31110
Purification Methods
Purify it by chromatography on silica gel, then recrystallise it from MeOH or EtOH (yellow needles). [Hodgson & Habeshaw J Chem Soc 47 1942, Bunce et al. J Org Chem 52 4214 1987, Beilstein 6 H 616, 6 III 2938.]
Properties of 1-METHOXY-4-NITRONAPHTHALENE
Melting point: | 83-85 °C (lit.) |
Boiling point: | 341.49°C (rough estimate) |
Density | 1.2621 (rough estimate) |
refractive index | 1.4950 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
Safety information for 1-METHOXY-4-NITRONAPHTHALENE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-METHOXY-4-NITRONAPHTHALENE
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
1-METHOXY-4-NITRONAPHTHALENE
1-Methoxynaphthalene
4-amino-1-naphthol
1-Naphthol
p-Anisidine
4-Nitrophenol
1-Naphthylamine
1-Nitronaphthalene
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