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HomeProduct name list1-METHOXY-4-NITRONAPHTHALENE

1-METHOXY-4-NITRONAPHTHALENE

  • CAS NO.:4900-63-4
  • Empirical Formula: C11H9NO3
  • Molecular Weight: 203.19
  • MDL number: MFCD00003926
  • EINECS: 225-528-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2022-11-11 11:01:00
1-METHOXY-4-NITRONAPHTHALENE Structural

What is 1-METHOXY-4-NITRONAPHTHALENE?

Chemical properties

yellow to orange crystalline powder

The Uses of 1-METHOXY-4-NITRONAPHTHALENE

1-Methoxy-4-nitronaphthalene is used as a reagent in the synthesis of UMI-77 (U700850); a small molecule inhibitor of Mcl-1 which blocks and attenuates pancreatic cell cancer growth. Also an anticancer agent.

Synthesis Reference(s)

Synthesis, p. 70, 1985 DOI: 10.1055/s-1985-31110

Purification Methods

Purify it by chromatography on silica gel, then recrystallise it from MeOH or EtOH (yellow needles). [Hodgson & Habeshaw J Chem Soc 47 1942, Bunce et al. J Org Chem 52 4214 1987, Beilstein 6 H 616, 6 III 2938.]

Properties of 1-METHOXY-4-NITRONAPHTHALENE

Melting point: 83-85 °C (lit.)
Boiling point: 341.49°C (rough estimate)
Density  1.2621 (rough estimate)
refractive index  1.4950 (estimate)
storage temp.  Sealed in dry,Room Temperature

Safety information for 1-METHOXY-4-NITRONAPHTHALENE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1-METHOXY-4-NITRONAPHTHALENE

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