1-Boc-Pyrrolidine

Synonym(s):tert-Butyl 1-pyrrolidinecarboxylate

CAS NO.：86953-79-9
Empirical Formula: C9H17NO2
Molecular Weight: 171.24
MDL number: MFCD00216581
EINECS: 617-940-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-04 16:55:17

What is 1-Boc-Pyrrolidine?

Chemical properties

liquid

The Uses of 1-Boc-Pyrrolidine

1-Boc-pyrrolidine is a boc-protected cyclic amine used as a building block in the preparation of diastereomers by usually undergoing α'-lithiations and electrophilic substitution reactions.

The Uses of 1-Boc-Pyrrolidine

N-Boc-pyrrolidine may be used in the synthesis of the following:

2-aryl-N-boc-pyrrolidines
scalemic 2-pyrrolidinylcuprates
2-alkenyl-N-Boc-pyrrolidines
1-deoxycastanospermine
methylphenidate analogues
(+)-elaeokanine A

General Description

N-Boc-pyrrolidine is an N-substituted pyrrolidine. It is reported that the reactivity of N-Boc-pyrrolidine towards C-H insertion reaction is 2000 times more than cyclohexane. It undergoes α-arylation in the presence of a palladium catalyst with high enantioselectivity.

Properties of 1-Boc-Pyrrolidine

Boiling point:	80 °C/0.2 mmHg (lit.)
Density	0.977 g/mL at 25 °C (lit.)
refractive index	n20/D 1.449(lit.)
Flash point:	187 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Oil
pka	-1.28±0.20(Predicted)
color	Clear Colorless
BRN	4664750
CAS DataBase Reference	86953-79-9(CAS DataBase Reference)

Safety information for 1-Boc-Pyrrolidine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.