1-Boc-4-methylpiperidine-4-carboxylic acid

CAS NO.：189321-63-9
Empirical Formula: C12H21NO4
Molecular Weight: 243.3
MDL number: MFCD02179132
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-10 09:07:12

What is 1-Boc-4-methylpiperidine-4-carboxylic acid?

Chemical properties

White to Light yellow powder to crystal

Synthesis

A mixture of Ethyl N-Boc-4-methylpiperidine-4-carboxylate (4.1 g, 15.1mmol) and lithium hydroxide (2.17g, 90.6mmol) in methanol (3OmL)ZH2O (2OmL) was stirred at a temperature of about 25 ℃ for 16h. After evaporation to dryness, the residue was partitioned between DCM and brine. The organic layer was separated, dried (MgSO4), filtered, and concentrated under reduced pressure to provide 3.38g of 1-Boc-4-methylpiperidine-4-carboxylic acid as a white solid (yield 92.0 percent).

Properties of 1-Boc-4-methylpiperidine-4-carboxylic acid

Boiling point:	354.3±35.0 °C(Predicted)
Density	1.129±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	4.69±0.20(Predicted)
InChI	InChI=1S/C12H21NO4/c1-11(2,3)17-10(16)13-7-5-12(4,6-8-13)9(14)15/h5-8H2,1-4H3,(H,14,15)
CAS DataBase Reference	189321-63-9(CAS DataBase Reference)

Safety information for 1-Boc-4-methylpiperidine-4-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.