Isonipecotic acid
Synonym(s):4-Piperidinecarboxylic acid;Hexahydroisonicotinic acid
- CAS NO.：498-94-2
- Empirical Formula: C6H11NO2
- Molecular Weight: 129.16
- MDL number: MFCD00006004
- EINECS: 207-872-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is Isonipecotic acid?
Chemical properties
white to faint pink-beige powder
The Uses of Isonipecotic acid
A GABA-A receptor partial agonist
What are the applications of Application
Isonipecotic acid is a HDAC inhibitor
Synthesis Reference(s)
Synthesis, p. 623, 1984
Tetrahedron Letters, 35, p. 8783, 1994 DOI: 10.1016/S0040-4039(00)78497-8
Description
Piperidine-4-carboxylic acid (4-Piperidinecarboxylic acid, 4-Carboxypiperidine, Hexahydroisonicotinic acid, Isonipecotic acid) belongs to the class of organic compounds known as piperidinecarboxylic acids. Piperidinecarboxylic acids are compounds containing a piperidine ring with a carboxylic acid group. piperidine-4-carboxylic acid is a strong basic compound (based on its pKa).
Purification Methods
It crystallises from H2O or EtOH as needles. The hydrochloride recrystallises from H2O or aqueous HCl with m 293odec (also 298odec, 300odec). [Wibaut Recl Trav Chim Pays-Bas 63 141 1944, IR: Zacharius et al. J Am Chem Soc 76 2908 1954, Beilstein 22/1 V 244.]
Properties of Isonipecotic acid
| Melting point: | >300 °C(lit.) |
| Boiling point: | 239.22°C (rough estimate) |
| Density | 1.1426 (rough estimate) |
| refractive index | 1.4587 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Water |
| pka | pK1:3.73(+1);pK2:10.72(0) (25°C) |
| form | Powder |
| color | White to faint pink-beige |
| Water Solubility | soluble |
| Merck | 14,5189 |
| BRN | 112553 |
| CAS DataBase Reference | 498-94-2(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Piperidinecarboxylic acid (498-94-2) |
Safety information for Isonipecotic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for Isonipecotic acid
Isonipecotic acid manufacturer
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