1-Aminobenzotriazole
Synonym(s):1-Benzotriazolamine;ABT
- CAS NO.:1614-12-6
- Empirical Formula: C6H6N4
- Molecular Weight: 134.14
- MDL number: MFCD00132902
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 1-Aminobenzotriazole?
Description
1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3
Chemical properties
yellow to beige or light brown crystalline powder
The Uses of 1-Aminobenzotriazole
1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.
The Uses of 1-Aminobenzotriazole
1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.
What are the applications of Application
1-Aminobenzotriazole is a suicide substrate for CYP-450 and chloroperoxidase
Biochem/physiol Actions
1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
References
1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43 2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351 3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426
Properties of 1-Aminobenzotriazole
Melting point: | 81-84 °C (lit.) |
Boiling point: | 237.24°C (rough estimate) |
Density | 1.2769 (rough estimate) |
RTECS | DM1235000 |
refractive index | 1.7000 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Soluble in DMSO (up to 30mg/ml) |
form | Crystalline Powder |
pka | 2.09±0.30(Predicted) |
color | Yellow to beige or light brown |
Water Solubility | slightly soluble |
BRN | 607843 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
CAS DataBase Reference | 1614-12-6(CAS DataBase Reference) |
Safety information for 1-Aminobenzotriazole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Aminobenzotriazole
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