1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

Synonym(s):1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

CAS NO.：147591-46-6
Empirical Formula: C16H14N2O4
Molecular Weight: 298.29
MDL number: MFCD00593367
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-15 19:19:13

1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Structural

What is 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol?

Description

ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2

The Uses of 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.

What are the applications of Application

ID 8 is which sustains self-renewal and pluripotency of mouse ESCs

General Description

ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).

Biochem/physiol Actions

ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).

storage

+4°C

References

1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18

Properties of 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

Melting point:	266 °C(dec.)
storage temp.	2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	yellow
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety information for 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.