1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Synonym(s):1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
- CAS NO.：147591-46-6
- Empirical Formula: C16H14N2O4
- Molecular Weight: 298.29
- MDL number: MFCD00593367
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol?
Description
ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2
The Uses of 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.
What are the applications of Application
ID 8 is which sustains self-renewal and pluripotency of mouse ESCs
General Description
ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Biochem/physiol Actions
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
storage
+4°C
References
1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18
Properties of 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
| Melting point: | 266 °C(dec.) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | yellow |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
New Products
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