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HomeProduct name list(-)-SPARTEINE

(-)-SPARTEINE

Synonym(s):(−)-Lupinidine

  • CAS NO.:90-39-1
  • Empirical Formula: C15H26N2
  • Molecular Weight: 234.38
  • MDL number: MFCD00069653
  • EINECS: 201-988-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
(-)-SPARTEINE Structural

What is (-)-SPARTEINE?

Description

Sparteine is effective against sinoatrial and atrial tachycardias, atrial extrasystoles, and also against ventricular arrhythmias . Despite prolongation of the myocardial refractory period in vitro, theECGtimes are not prolonged in vivo.

Chemical properties

Viscous oily liquid; boils around 180°C(356°F); density 1.02 at 20°C (68°F); stronglybasic, a 0.01 M soln. has pH 11.6; slightlysoluble in water (0.3 g/100 mL), dissolvesreadily in alcohol, ether, or chloroform.

The Uses of (-)-SPARTEINE

Sparteine occurs in yellow and black lupinbeans (Lupinus luteus L. and L. niger). Italso occurs in other Lupinus species aswell as in Cytisus and Spartium species.Therapeutically, it is used as an oxytocicagent.

Definition

ChEBI: Sparteine is a quinolizidine alkaloid and a quinolizidine alkaloid fundamental parent.

Health Hazard

Toxic actions of sparteine are similar to thoseof coniine but are much less toxic than thoseof coniine. The toxic symptoms in mice weretremor, muscle contraction, and respiratorydistress. An intraperitoneal dose lethal toguinea pigs is 23 mg/kg.
LD50 value, oral (mice): 220 mg/kg.

Properties of (-)-SPARTEINE

Melting point: 30.5°C
Boiling point: 137-138 °C1 mm Hg(lit.)
alpha  D21 -16.4° (c = 10 in abs alc)
Density  1.02 g/mL at 25 °C(lit.)
refractive index  n20/D 1.528(lit.)
Flash point: >230 °F
storage temp.  2-8°C
solubility  Chloroform (Slightly), Ethanol (Slightly)
form  liquid
pka 2.24, 9.46(at 20℃)
color  Light Yellow to Yellow
optical activity [α]/D -17.5±1.5°, c = 1 in ethanol
Water Solubility  3.04g/L(25 ºC)
Merck  14,8737
BRN  82447

Safety information for (-)-SPARTEINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for (-)-SPARTEINE

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