(-)-SPARTEINE
Synonym(s):(−)-Lupinidine
- CAS NO.:90-39-1
- Empirical Formula: C15H26N2
- Molecular Weight: 234.38
- MDL number: MFCD00069653
- EINECS: 201-988-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is (-)-SPARTEINE?
Description
Sparteine is effective against sinoatrial and atrial tachycardias, atrial extrasystoles, and also against ventricular arrhythmias . Despite prolongation of the myocardial refractory period in vitro, theECGtimes are not prolonged in vivo.
Chemical properties
Viscous oily liquid; boils around 180°C(356°F); density 1.02 at 20°C (68°F); stronglybasic, a 0.01 M soln. has pH 11.6; slightlysoluble in water (0.3 g/100 mL), dissolvesreadily in alcohol, ether, or chloroform.
The Uses of (-)-SPARTEINE
Sparteine occurs in yellow and black lupinbeans (Lupinus luteus L. and L. niger). Italso occurs in other Lupinus species aswell as in Cytisus and Spartium species.Therapeutically, it is used as an oxytocicagent.
Definition
ChEBI: Sparteine is a quinolizidine alkaloid and a quinolizidine alkaloid fundamental parent.
Health Hazard
Toxic actions of sparteine are similar to thoseof coniine but are much less toxic than thoseof coniine. The toxic symptoms in mice weretremor, muscle contraction, and respiratorydistress. An intraperitoneal dose lethal toguinea pigs is 23 mg/kg.
LD50 value, oral (mice): 220 mg/kg.
Properties of (-)-SPARTEINE
Melting point: | 30.5°C |
Boiling point: | 137-138 °C1 mm Hg(lit.) |
alpha | D21 -16.4° (c = 10 in abs alc) |
Density | 1.02 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Ethanol (Slightly) |
form | liquid |
pka | 2.24, 9.46(at 20℃) |
color | Light Yellow to Yellow |
optical activity | [α]/D -17.5±1.5°, c = 1 in ethanol |
Water Solubility | 3.04g/L(25 ºC) |
Merck | 14,8737 |
BRN | 82447 |
Safety information for (-)-SPARTEINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for (-)-SPARTEINE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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