(-)-SPARTEINE
Synonym(s):(−)-Lupinidine
- CAS NO.:90-39-1
- Empirical Formula: C15H26N2
- Molecular Weight: 234.38
- MDL number: MFCD00069653
- EINECS: 201-988-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is (-)-SPARTEINE?
Description
Sparteine is effective against sinoatrial and atrial tachycardias, atrial extrasystoles, and also against ventricular arrhythmias . Despite prolongation of the myocardial refractory period in vitro, theECGtimes are not prolonged in vivo.
Chemical properties
Viscous oily liquid; boils around 180°C(356°F); density 1.02 at 20°C (68°F); stronglybasic, a 0.01 M soln. has pH 11.6; slightlysoluble in water (0.3 g/100 mL), dissolvesreadily in alcohol, ether, or chloroform.
The Uses of (-)-SPARTEINE
Sparteine occurs in yellow and black lupinbeans (Lupinus luteus L. and L. niger). Italso occurs in other Lupinus species aswell as in Cytisus and Spartium species.Therapeutically, it is used as an oxytocicagent.
Definition
ChEBI: Sparteine is a quinolizidine alkaloid and a quinolizidine alkaloid fundamental parent.
Health Hazard
Toxic actions of sparteine are similar to thoseof coniine but are much less toxic than thoseof coniine. The toxic symptoms in mice weretremor, muscle contraction, and respiratorydistress. An intraperitoneal dose lethal toguinea pigs is 23 mg/kg.
LD50 value, oral (mice): 220 mg/kg.
Properties of (-)-SPARTEINE
Melting point: | 30.5°C |
Boiling point: | 137-138 °C1 mm Hg(lit.) |
alpha | D21 -16.4° (c = 10 in abs alc) |
Density | 1.02 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Ethanol (Slightly) |
form | liquid |
pka | 2.24, 9.46(at 20℃) |
color | Light Yellow to Yellow |
optical activity | [α]/D -17.5±1.5°, c = 1 in ethanol |
Water Solubility | 3.04g/L(25 ºC) |
Merck | 14,8737 |
BRN | 82447 |
Safety information for (-)-SPARTEINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for (-)-SPARTEINE
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION XANTHAN GUM Racecadotril SODIUM VALPROATE Diclofenac Sodium Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN Folic Acid Impurity G Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Glycopyrronium Bromide EP Impurity I Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
You may like
-
(−)-Sparteine CAS 90-39-1View Details
90-39-1 -
88150-47-4 99%View Details
88150-47-4 -
177-11-7 1,4-Dioxa-8-azaspiro[4.5]decane 98+View Details
177-11-7 -
217299-03-1 98+View Details
217299-03-1 -
(R)-3-Aminobutanenitrile Hydrochloride 98+View Details
1073666-55-3 -
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 39124-20-4 98+View Details
39124-20-4 -
2006278-26-6 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 98+View Details
2006278-26-6 -
39856-50-3 98+View Details
39856-50-3