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HomeProduct name list(±)-Cloprostenol sodium salt

(±)-Cloprostenol sodium salt

Synonym(s):(+/-)-16-(3-Chlorophenoxy)-9,11,15R-trihydroxy-17,18,19,20-tetranorprosta-5Z,13E-dien-1-oic acid sodium salt hydrate;(+/-)-Cloprostenol sodium salt hydrate;Cloprostenol sodium salt

  • CAS NO.:55028-72-3
  • Empirical Formula: C22H30ClNaO6
  • Molecular Weight: 448.92
  • MDL number: MFCD00132875
  • EINECS: 259-439-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
(±)-Cloprostenol sodium salt Structural

What is (±)-Cloprostenol sodium salt?

The Uses of (±)-Cloprostenol sodium salt

(±)-Cloprostenol sodium salt is a prostaglandin that dissolves the corpus luteum of cattle and is used as a veterinary drug.

Description

±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.

What are the applications of Application

Cloprostenol Sodium is a potent FP agonist

brand name

Estrumate(Bayer Animal Health).

General Description

Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL.

Biological Activity

Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo .

Side Effects

A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection.
Very rarely, anaphylactic reactions have occurred after administration of the product. Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown.

Veterinary Drugs and Treatments

Cloprostenol is approved for use in beef or dairy cattle to induce luteolysis. It is recommended by the manufacturer for unobserved or undetected estrus in cows cycling normally, pyometra or chronic endometritis, expulsion of mummified fetus, luteal cysts, induced abortions after mismating, and to schedule estrus and ovulation for controlled breeding.
Cloprostenol has been used in dogs for pregnancy termination and treatment of open pyometra. The use of cloprostenol for pyometra is controversial as some believe dinoprost (PGF2alpha) is more effective and has fewer adverse effects than cloprostenol.

Solubility in water

Soluble in H2O.

Properties of (±)-Cloprostenol sodium salt

Melting point: 68-70 °C
storage temp.  Inert atmosphere,Store in freezer, under -20°C
solubility  H2O: >10 mg/mL
form  solid
color  light brown
CAS DataBase Reference 55028-72-3(CAS DataBase Reference)

Safety information for (±)-Cloprostenol sodium salt

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for (±)-Cloprostenol sodium salt

InChIKey IFEJLMHZNQJGQU-KXXGZHCCSA-M

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