(±)-Cloprostenol sodium salt
Synonym(s):(+/-)-16-(3-Chlorophenoxy)-9,11,15R-trihydroxy-17,18,19,20-tetranorprosta-5Z,13E-dien-1-oic acid sodium salt hydrate;(+/-)-Cloprostenol sodium salt hydrate;Cloprostenol sodium salt
- CAS NO.:55028-72-3
- Empirical Formula: C22H30ClNaO6
- Molecular Weight: 448.92
- MDL number: MFCD00132875
- EINECS: 259-439-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is (±)-Cloprostenol sodium salt?
The Uses of (±)-Cloprostenol sodium salt
(±)-Cloprostenol sodium salt is a prostaglandin that dissolves the corpus luteum of cattle and is used as a veterinary drug.
Description
±)-Cloprostenol sodium salt is the d-enantiomer of Cloprostenol (C587300), an aryl-oxymethyl analog of prostaglandin F2α.
What are the applications of Application
Cloprostenol Sodium is a potent FP agonist
brand name
Estrumate(Bayer Animal Health).
General Description
Cloprostenol sodium (Estrumate)is available as the sodium salt from Bayer AgriculturalDivision or Bayvet Division of Miles Laboratory as an aqueoussolution containing 250 mg/mL.
Biological Activity
Water-soluble prostaglandin F 2 α (PGF 2 α ) analog; acts as a potent FP receptor agonist (EC 50 = 0.84 nM). Potently inhibits differentiation of adipocyte precursor cells. Luteolytic agent in vivo .
Side Effects
A low incidence of clostridial and other infections at the injection site has been reported following prostaglandin administration. Treated animals should be closely observed post injection and appropriate antibiotic therapy initiated at the first sign(s) of infection.
Very rarely, anaphylactic reactions have occurred after administration of the product. Overdose: At 50 and 100 times the recommended dose of cloprostenol mild side effects may be detected. These include increased uneasiness, mild transient diarrhea, slight frothing, and milk letdown.
Veterinary Drugs and Treatments
Cloprostenol is approved for use in beef or dairy cattle to induce
luteolysis. It is recommended by the manufacturer for unobserved
or undetected estrus in cows cycling normally, pyometra or chronic
endometritis, expulsion of mummified fetus, luteal cysts, induced
abortions after mismating, and to schedule estrus and ovulation for
controlled breeding.
Cloprostenol has been used in dogs for pregnancy termination
and treatment of open pyometra. The use of cloprostenol for pyometra
is controversial as some believe dinoprost (PGF2alpha) is
more effective and has fewer adverse effects than cloprostenol.
Solubility in water
Soluble in H2O.
Properties of (±)-Cloprostenol sodium salt
Melting point: | 68-70 °C |
storage temp. | Inert atmosphere,Store in freezer, under -20°C |
solubility | H2O: >10 mg/mL |
form | solid |
color | light brown |
CAS DataBase Reference | 55028-72-3(CAS DataBase Reference) |
Safety information for (±)-Cloprostenol sodium salt
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for (±)-Cloprostenol sodium salt
InChIKey | IFEJLMHZNQJGQU-KXXGZHCCSA-M |
Abamectin manufacturer
Piramal Pharma Solutions
Aspen Biopharma Labs Pvt Ltd
Apionex Pharma Pvt Ltd
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