Beraprost sodium
Synonym(s):2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3-hydroxy-4-methyl-1-octen-6-ynyl)-1H-cyclopenta(b)benzofuran-5-butanoic acid sodium salt;Procyclin;TRK 100
- CAS NO.:88475-69-8
- Empirical Formula: C24H29NaO5
- Molecular Weight: 420.47
- MDL number: MFCD00911570
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-14 10:14:29
What is Beraprost sodium?
Description
Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP in platelets which is achieved by activating adenylate cyclase in the platelet membrane, followed by the inhibition ofCa++- influx and thromboxane A2 formation.
Description
Beraprost is an analog of prostacyclin in which the unstable enol-
Chemical properties
White Solid
Originator
Toray (Japan)
The Uses of Beraprost sodium
Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).
What are the applications of Application
Beraprost sodium salt is an analog of prostacyclin which inhibits platelet aggregation
Definition
ChEBI: Beraprost sodium is the organic sodium salt of beraprost. It is used in the treatment of chronic arterial occlusive disease and primary pulmonary hypertension in Japan. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, a prostaglandin receptor agonist, a vasodilator agent and an anti-inflammatory agent. It contains a beraprost(1-).
brand name
Dorner; Dorner;Procylin
General Description
Beraprost sodium is an orally active prostacyclin analog.
Biochem/physiol Actions
Beraprost sodium is used as a therapeutic agent for chronic artery obstructions or primary pulmonary hypertension. In individuals with coronary artery disease, beraprost sodium helps to reduce oxidative stress and developed forearm endothelium dependent vasodilation.
Side Effects
Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.
Properties of Beraprost sodium
Melting point: | 204-206°C |
storage temp. | -20°C |
solubility | DMF:77.0(Max Conc. mg/mL);183.12(Max Conc. mM) Ethanol:20.0(Max Conc. mg/mL);47.56(Max Conc. mM) PBS (pH 7.2):19.0(Max Conc. mg/mL);45.19(Max Conc. mM) |
form | powder |
color | white to beige |
CAS DataBase Reference | 88475-69-8(CAS DataBase Reference) |
Safety information for Beraprost sodium
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Beraprost sodium
InChIKey | YTCZZXIRLARSET-LIIFYGAANA-M |
SMILES | [C@H]12[C@H](C[C@@H](O)[C@@H]1/C=C/[C@@H](O)C(C)CC#CC)OC1C(=CC=CC2=1)CCCC([O-])=O.[Na+] |&1:0,1,3,5,8,r| |
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