(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide

CAS NO.：1176658-85-7
Empirical Formula: C26H36F3NO7
Molecular Weight: 531.56
MDL number: MFCD08062130
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide?

Description

2-arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB₁ receptor, is an important endogenous monoglyceride species, and is thus considered to be the natural ligand for the CB₁ receptor. 2-AG can also be metabolized by cyclooxygenase-2 and specific prostaglandin H₂ (PGH₂) isomerases to form PG 2-glyceryl esters. Fluprostenol serinol amide (Flu-SA) is a stable analog of PGF_2α 2-glyceryl ester that has much greater stability. The biological activity of Flu-SA has not yet been determined.

Definition

ChEBI: Fluprostenol serinol amide is a prostanoid.

Properties of (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide

Boiling point:	749.4±60.0 °C(Predicted)
Density	1.330±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
pka	13.43±0.20(Predicted)

Safety information for (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide

Computed Descriptors for (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]-N-(1,3-dihydroxypropan-2-yl)hept-5-enamide

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