9-keto Fluprostenol isopropyl ester
- CAS NO.:1219032-18-4
- Empirical Formula: C26H33F3O6
- Molecular Weight: 498.53
- MDL number: MFCD02259341
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is 9-keto Fluprostenol isopropyl ester?
The Uses of 9-keto Fluprostenol isopropyl ester
Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.
The Uses of 9-keto Fluprostenol isopropyl ester
9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Properties of 9-keto Fluprostenol isopropyl ester
Boiling point: | 583.6±50.0 °C(Predicted) |
Density | 1.241±0.06 g/cm3(Predicted) |
solubility | DMF: 30 mg/ml; DMF:PBS (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml |
pka | 13.32±0.20(Predicted) |
Safety information for 9-keto Fluprostenol isopropyl ester
Computed Descriptors for 9-keto Fluprostenol isopropyl ester
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