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Home Product name list11-KETO FLUPROSTENOL

11-KETO FLUPROSTENOL

CAS NO.：62145-07-7
Empirical Formula: C23H27F3O6
Molecular Weight: 456.45
MDL number: MFCD05863541
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 09:03:09

11-KETO FLUPROSTENOL Structural

What is 11-KETO FLUPROSTENOL?

Description

11-keto Fluprostenol is an analog of prostaglandin D₂ (PGD₂) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF_2α and acts primarily through the FP receptor.¹ Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP₂ receptor compared to PGD₂ and essentially no activity at the DP₁ receptor.²

What are the applications of Application

11-keto Fluprostenol is An analog of prostaglandin D2

Definition

ChEBI: 11-keto Fluprostenol is a prostanoid.

References

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F_2α Nature 250(464),330-331(1974).
2. Monneret, G., Cossette, C., Gravel, S., et al. 15R-methyl-prostaglandin D₂ is a potent and selective CRTH2/DP₂ receptor agonist in human eosinophils J. Pharmacol. Exp. Ther. 304(1),349-355(2003).

Properties of 11-KETO FLUPROSTENOL

Boiling point:	627.3±55.0 °C(Predicted)
Density	1.331±0.06 g/cm3(Predicted)
solubility	PBS (7.2): 29 mg/ml
pka	4.76±0.10(Predicted)

Safety information for 11-KETO FLUPROSTENOL

Computed Descriptors for 11-KETO FLUPROSTENOL

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