11-KETO FLUPROSTENOL

Description

11-keto Fluprostenol is an analog of prostaglandin D₂ (PGD₂) with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF_2α and acts primarily through the FP receptor.¹ Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP₂ receptor compared to PGD₂ and essentially no activity at the DP₁ receptor.²

What are the applications of Application

11-keto Fluprostenol is An analog of prostaglandin D2

Definition

ChEBI: 11-keto Fluprostenol is a prostanoid.

References

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F_2α Nature 250(464),330-331(1974).
2. Monneret, G., Cossette, C., Gravel, S., et al. 15R-methyl-prostaglandin D₂ is a potent and selective CRTH2/DP₂ receptor agonist in human eosinophils J. Pharmacol. Exp. Ther. 304(1),349-355(2003).