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Volitinib

Volitinib Structural

What is Volitinib?

Description

Savolitinib selectively inhibits the MET receptor, blocking the PI3K/AKT/MAPK-signaling pathway as well as downregulating MYC.

The Uses of Volitinib

Savolitinib is a potent and highly selective c-Met inhibitor. Savoltinib demonstrated anti-tumor efficacy in a panel of cMet-dysregulated gastric cancer PDX models. Savolitinib also demonstrated good antitmuor activities.

Clinical Use

It is currently being evaluated in phase I clinical trials in combination with EGFR TKIs in NSCLC patients.

Properties of Volitinib

Melting point: 205-207°C
Density  1.55±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
pka 5.67±0.50(Predicted)
form  Solid
color  Pale Beige
CAS DataBase Reference 1313725-88-0

Safety information for Volitinib

Computed Descriptors for Volitinib

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