Vidarabine monophosphate
- CAS NO.：29984-33-6
- Empirical Formula: C10H14N5O7P
- Molecular Weight: 347.22
- MDL number: MFCD00069723
- EINECS: 249-990-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:21
What is Vidarabine monophosphate?
Description
Vidarabine monophosphate, chemical name: 9-(5-O-Phosphono-beta-D-arabinofuranosyl)adenine is an anti deoxyribonucleic acid virus drug. IVidarabine triphosphate directly inhibits DNA polymerase and also acts as a chain terminator in DNA replication. An adenosine monophosphate analog in which ribose is replaced by an arabinose moiety. It is the monophosphate ester of VIDARABINE with antiviral and possibly antineoplastic properties.
Chemical properties
Crystalline
The Uses of Vidarabine monophosphate
Antiviral.
The Uses of Vidarabine monophosphate
Disrupts viral DNA synthesis. Competitive viral DNA polymerase inhibitor. Active against herpes simplex and varicella zoster viruses in vivo.
What are the applications of Application
Vidarabine monophosphate has broad-spectrum anti-virus effect and can inhibit a variety of DNA viruses. It is mainly used to treat chronic hepatitis B and other viral infections, such as herpes zoster, herpes simplex and genital herpes. It has quick effect and clear curative effect. It is a common drug for clinical anti-virus treatment.
Safety Profile
Moderately toxic byintraperitoneal route. When heated to decomposition itemits very toxic fumes of POx and NOx.
Properties of Vidarabine monophosphate
| Melting point: | 213 °C |
| Boiling point: | 798.5±70.0 °C(Predicted) |
| Density | 2.32±0.1 g/cm3(Predicted) |
| storage temp. | Store at 0°C |
| form | Powder |
| pka | 1.86±0.10(Predicted) |
| color | White to Off-white |
| Water Solubility | Soluble in water at 4mg/ml |
Safety information for Vidarabine monophosphate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Vidarabine monophosphate
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