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HomeProduct name listVanadinocene Dichloride

Vanadinocene Dichloride

Synonym(s):Di-π-Cyclopentadienylvanadium dichloride;Dichlorobis(cyclopentadienyl)vanadium;Dichlorovanadocene;Vanadocene dichloride

  • CAS NO.:12083-48-6
  • Empirical Formula: C10H10Cl2V10*
  • Molecular Weight: 252.03
  • MDL number: MFCD00014260
  • EINECS: 235-150-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-10-17 17:11:57
Vanadinocene Dichloride Structural

What is Vanadinocene Dichloride?

Chemical properties

dark green crystalline powder

The Uses of Vanadinocene Dichloride

Vanadocene dichloride is used like other metallocenes as a catalyst, ultraviolet absorber, reducing agent, free radical scavenger, antiknock agent in gasoline, and as a developmental anticancer drug.

The Uses of Vanadinocene Dichloride

Bis(cyclopentadienyl)vanadium(IV) dichloride is a catalyst for solvent free, room temperature preparation of vicinal amino alcohols as fungistatic agents, catalyst fot oligomerization reactions via the Aufbau propagation reaction and as a catalyst for aqueous polymerization reactions using oxygen as a co catalyst. It is used as a catalyst for dl-selective pinacol-type coupling reactions, as an affecter of crystal growth of calcium carbonate and and as an inhibitor of human topoisomerase II enzyme with antitumor activity.

What are the applications of Application

Bis(cyclopentadienyl)vanadium(IV) dichloride is a useful catalyst

General Description

Pale green crystals or green powder.

Air & Water Reactions

Extremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water

Reactivity Profile

Organometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.

Fire Hazard

Flash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.

Pharmaceutical Applications

Vanadocene dichloride [( η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.

Pharmaceutical Applications

Vanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing.

Properties of Vanadinocene Dichloride

Melting point: 182-194 °C (dec.)(lit.)
Density  1,6 g/cm3
storage temp.  2-8°C
solubility  soluble in H2O, chloroform, ethanol
form  crystal
color  green
Specific Gravity 1.6
Water Solubility  Reacts with water
Sensitive  Air & Moisture Sensitive
Exposure limits NIOSH: Ceiling 0.05 mg/m3
CAS DataBase Reference 12083-48-6(CAS DataBase Reference)
EPA Substance Registry System Vanadocene dichloride (12083-48-6)

Safety information for Vanadinocene Dichloride

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for Vanadinocene Dichloride

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